急腹症术后患儿应用醋酸奥曲肽治疗的临床效果研究  

Clinical Effect of Octreotide Acetate in the Treatment of Children with Acute Abdomen after Surgery

作　　者：黄振文 吕昌恒[1] 唐海洲[1] 张东虎 杨迪 何昌景 罗克德 HUANG Zhenwen;LV Changheng;TANG Haizhou;ZHANG Donghu;YANG Di;HE Changjing;LUO Kede(Pediatric Surgery,Affiliated Hospital of Youjiang Medical College for Nationalities,Baise,Guangxi Zhuang Autonomous Region,533000 China)

机构地区：[1]右江民族医学院附属医院小儿外科,广西百色533000

出　　处：《系统医学》2022年第9期159-162,共4页Systems Medicine

摘　　要：目的探讨急腹症术后患儿应用醋酸奥曲肽治疗的临床效果。方法选取2017年3月—2021年4月该院收治的120例急腹症患儿作为研究对象,用随机数表法将其分为对照组和观察组,各60例,两组患儿均接受手术治疗,术后对照组接受常规抗感染治疗,观察组在常规抗感染基础上,接受醋酸奥曲肽治疗,比较两组患儿治疗前后腹内压、胃肠功能恢复时间、血尿淀粉酶指标、并发症等。结果术前、术后第1天,两组患儿腹内压比较,差异无统计学意义(t=0.053、0.694,P>0.05),术后第3天、术后第5天,观察组腹内压[(12.02±1.21)、(4.24±0.21)cmH_(2)O]低于对照组[(15.69±1.32)、(9.25±0.36)cmH_(2)O],差异有统计学意义(t=15.875、93.113,P<0.05);观察组首次排气时间、肠鸣音恢复时间、首次排便时间短于对照组,差异有统计学意义(t=33.482、12.393、60.083,P<0.05),术前两组患儿血淀粉酶、尿淀粉酶指标比较,差异无统计学意义(t=0.031、0.022,P>0.05),术后第3天、第5天,观察组血淀粉酶、尿淀粉酶水平低于对照组,差异有统计学意义(t=30.283、28.912、44.376、37.816,P<0.05);观察组并发症发生率8.33%低于对照组10.00%,但差异无统计学意义(χ^(2)=0.100,P>0.05)。结论急腹症患儿术后接受醋酸奥曲肽治疗,其血尿淀粉酶指标改善更为明显,可降低腹内压和并发症发生率,利于术后恢复。Objective To investigate the clinical effect of octreotide acetate in the treatment of children with acute abdomen after surgery.Methods A total of 120 children with acute abdomen who were admitted to the hospital from March 2017 to April 2021 were selected as the research objects.They were divided into control group and observation group by random number table method,60 cases in each group.Both groups of children received surgical treatment,the control group received conventional anti-infective treatment after operation,and the observation group received octreotide acetate treatment on the basis of conventional anti-infection.The intra-abdominal pressure,gastrointestinal function recovery time,blood and urine amylase indexes,and complications rate were compared between the two groups before and after treatment.Results There was no statistically significant difference in intra-abdominal pressure between the two groups before surgery and on the first day after surgery(t=0.053,0.694,P>0.05).On the 3rd day and 5th day,the internal pressure of observation group[(12.02±1.21)cmH_(2)O,(4.24±0.21)cmH_(2)O]was lower than the control group[(15.69±1.32)cmH_(2)O,(9.25±0.36)cmH_(2)O],the difference was statistically significant(t=15.875,93.113,P<0.05).The time to first exhaust,the time to recover bowel sounds,and the time to first defecation in the observation group were shorter than those in the control group,and the differences were statistically significant(t=33.482,12.393,60.083,P<0.05).There was no statistically significant difference in blood amylase and urine amylase between the two groups before surgery(t=0.031,0.022,P>0.05).On the 3rd and 5th day after operation,the blood amylase and urine amylase level of the observation group were lower than those of the control group,and the difference was statistically significant(t=30.283,28.912,44.376,37.816,P<0.05).The incidence of complications in the observation group was 8.33%,lower than that in the control group,which was 10.00%,but the difference was not statistically

关 键 词：急腹症 醋酸奥曲肽 腹内压 小儿 

分 类 号：R4[医药卫生—临床医学]