住院老年2型糖尿病患者临床指标与甲状腺功能的相关分析  

Correlation Analysis of Clinical Indicators and Thyroid Function in Hospitalized Elderly Patients with Type 2 Diabetes Mellitus

作　　者：吴智勇 徐永霞[1] 王芬[1] 惠灿灿 程雨微 孙艳[1] WU Zhiyong;XU Yongxia;WANG Fen;HUI Cancan;CHENG Yuwei;SUN Yan(Department of Endocrinology,Cadre Ward,the First Affiliated Hospital of Anhui Medical University,Hefei,Anhui Province,230022 China)

机构地区：[1]安徽医科大学第一附属医院干部病房内分泌科,安徽合肥230022

出　　处：《系统医学》2022年第6期14-18,共5页Systems Medicine

基　　金：国家自然科学基金(82072134);安徽省高校自然科学基金重点项目(KJ2018A0196);安徽医科大学第一附属医院博士课题(2017-1208)。

摘　　要：目的通过分析住院老年2型糖尿病患者临床指标、甲状腺功能及抗体的状况,探讨老年2型糖尿病与甲状腺疾病可能存在的相关性。方法选取2019年1—12月于干部病房内分泌科住院的240例2型糖尿病患者,根据患者年龄分为非老年组(113例,年龄≤60岁)和老年组(127例,年龄>60岁),回顾性分析其临床资料及甲状腺相关指标(T3、T4、TSH、TPOAb、TgAb、Tg),探讨老年2型糖尿病与甲状腺疾病可能存在的关联。结果老年组年龄、病程、收缩压、舒张压、空腹血糖、白蛋白、胱抑素、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、极低密度脂蛋白胆固醇、脂蛋白a及铁蛋白与非老年组相比,差异有统计学意义(P<0.05)。老年组甲状腺相关指标中TSH(2.73±1.48)uIU/mL、TPOAb(138.81±264.42)IU/mL与非老年组相比,差异有统计学意义(t=-2.583、-2.257,P<0.05)。Pearson相关线性分析提示年龄与糖尿病病程、TSH呈显著正相关(P<0.01),与TPOAb呈正相关(P<0.05),空腹血糖与T4呈正相关(P<0.05)。结论与非老年2型糖尿病患者比较,老年2型糖尿病患者血压、血脂、炎症指标及甲状腺功能等存在显著差异。随着年龄增长,2型糖尿病患者出现甲状腺免疫状况紊乱及发生甲状腺功能减退的风险更大。Objective To analyze the clinical indicators,thyroid function and antibody status of hospitalized elderly patients with type 2 diabetes.To explore the possible correlation between type 2 diabetes mellitus and thyroid disease in the elderly.Methods A total of 240 patients with type 2 diabetes who were hospitalized in the Department of Endocrinology in the cadre ward from January to December 2019 were selected.According to the age of patients,they were divided into non-elderly group(113 cases,age≤60 years old)and elderly group(127 cases,age>60 years old).The clinical data and thyroid-related indexes(T3,T4,TSH,TPOAb,TgAb,Tg)were retrospectively analyzed.To explore the possible association between type 2 diabetes mellitus and thyroid disease in the elderly.Results Age,disease course,systolic blood pressure,diastolic blood pressure,fasting blood glucose,albumin,cystatin,total cholesterol,triglyceride,high density lipoprotein cholesterol,very low density lipoprotein cholesterol,lipoprotein a and iron in the elderly group compared with the non-elderly group,the difference was statistically significant(P<0.05).Compared with the non-elderly group,the TSH(2.73±1.48)uIU/mL and TPOAb(138.81±264.42)IU/mL of the thyroid-related indexes in the elderly group,the difference was statistically significant(t=-2.583,-2.257,P<0.05).Pearson correlation linear analysis showed that age was positively correlated with diabetes duration and TSH(P<0.01),positively correlated with TPOAb(P<0.05),and fasting blood glucose was positively correlated with T4(P<0.05).Conclusion Compared with non-elderly patients with type 2 diabetes,the elderly patients with type 2 diabetes have significant differences in blood pressure,blood lipids,inflammatory indicators and thyroid function.Patients with type 2 diabetes are at greater risk for a disordered immune thyroid status and hypothyroidism as they age.

关 键 词：老年人 2型糖尿病 甲状腺 

分 类 号：R4[医药卫生—临床医学]