TOMM40基因多态性及基因-环境交互作用对血管性痴呆的影响  

Effects of TOMM40 Gene Polymorphism and Gene-environment Interaction on Vascular Dementia

作　　者：马玥[1] 张鹏 卢杉 MA Yue;ZHANG Peng;LU Shan(The Second Department of Neurology,Heilongjiang Provincial Hospital,Harbin,Heilongjiang Province,150000 China;Department of Geriatric Neurology,Heilongjiang Provincial Hospital,Harbin,Heilongjiang Province,150000 China;Department of Medical Imaging,Heilongjiang Provincial Hospital,Harbin,Heilongjiang Province,150000 China)

机构地区：[1]黑龙江省医院神经内二科,黑龙江哈尔滨150000 [2]黑龙江省医院老年神经内科,黑龙江哈尔滨150000 [3]黑龙江省医院医学影像科,黑龙江哈尔滨150000

出　　处：《系统医学》2022年第6期25-28,共4页Systems Medicine

基　　金：黑龙江省卫生健康委科研课题(2020-260)。

摘　　要：目的探讨TOMM40基因多态性与环境因素及基因-环境的交互作用对黑龙江地区的血管性痴呆患者的影响,为未来防治血管性痴呆的发生发展提供研究方向。方法选取2020年6月—2021年6月门诊及住院治疗的100例血管性痴呆患者为病例组,同时选取无认知功能障碍的健康老年人100名作为随机对照组。采用流行病学进行问卷调查,以环境因素为变量,通过统计学分析环境因素对于血管性痴呆发病情况的作用;使用PCR实验方法数据分析血管性痴呆患者和TOMM40基因多态性的相关性。结果以标准化回归系数判断自变量对因变量的影响,经过分析发现生活饮食、气温气候是血管性痴呆患者的影响因素(t=4.100、-2.230,P<0.05);TOMM40的rs2075650位点基因型分布与血管性痴呆发病风险相关(OR=0.687,P<0.05),提示以上位点可能改变基因功能,并最终影响血管性痴呆的发生与发展。结论血管性痴呆患者发病因素和TOMM40基因位点的多态性呈密切相关;血管性痴呆患者的患病和黑龙江省内地区环境气候因素呈密切相关;因此基因-环境两因素的发生引发的交互作用与血管性痴呆患者患病的发生发展中起到十分重要的作用。Objective To investigate the effect of TOMM40 gene polymorphism,environmental factors and gene-environment interaction on vascular dementia patients in Heilongjiang.To provide research directions for the prevention and treatment of vascular dementia in the future.Methods A total of 100 patients with vascular dementia who received outpatient and inpatient treatment from June 2020 to June 2021 were selected as the case group,and 100 healthy elderly without cognitive impairment were selected as the random control group.An epidemiological survey was conducted,and environmental factors were used as variables to analyze the effect of environmental factors on the incidence of vascular dementia through statistical analysis.The correlation between vascular dementia patients and TOMM40 gene polymorphism was analyzed using PCR experimental data.Results Standardized regression coefficient was used to judge the influence of independent variables on dependent variables.After analysis,it was found that life,diet,temperature and climate were the influencing factors of patients with vascular dementia(F=4.100,-2.230,P<0.05).The genotype distribution of the rs2075650 locus of TOMM40 was associated with the risk of vascular dementia(OR=0.687,P<0.05).It is suggested that the above loci may change gene function and ultimately affect the occurrence and development of vascular dementia.Conclusion The pathogenesis of vascular dementia is closely related to the polymorphism of TOMM40 gene locus.The prevalence of vascular dementia patients is closely related to environmental and climatic factors in Heilongjiang Province.Therefore,the interaction caused by the occurrence of gene-environmental factors plays a very important role in the occurrence and development of vascular dementia patients.

关 键 词：血管性痴呆 TOMM40 基因多态性 基因-环境因素 

分 类 号：R4[医药卫生—临床医学]