糖尿病肾病不同进展阶段血清炎症因子的检测与评价  

Detection and Evaluation of Serum Inflammatory Factors in Different Stages of Diabetic Nephropathy

作　　者：肖燕萍[1] 苏光建[1] 陈秀[1] 彭伟[1] XIAO Yanping;SU Guangjian;CHEN Xiu;PENG Wei(Department of Laboratory Medicine,Fujian Cancer Hospital,Fuzhou,Fujian Province,350001 China)

机构地区：[1]福建省肿瘤医院检验科,福建福州350001

出　　处：《糖尿病新世界》2022年第8期16-19,共4页Diabetes New World Magazine

摘　　要：目的 探讨糖尿病肾病不同进展阶段血清炎症因子的检测与评价。方法 选择该院2019年2月—2021年3月收治的糖尿病肾病患者100例为观察组。同时纳入同期的健康体检者100名为对照组。检测两组脂蛋白相关磷脂酶A2(LP-PLA2)、白细胞介素1β(IL-1β)、白细胞介素6(IL-6)、血清C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、血清胱抑素C(Cys C)、中性粒细胞百分比(NEU%%)及白细胞计数(WBC)等血清炎症因子指标;同时检测两组糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)血纤维蛋白原(FIB)、高密度脂蛋白胆固醇(HDL-C)以及低密度脂蛋白胆固醇(LDL-C)等指标,及尿微量白蛋白(ALB)、血肌酐(Scr)、血尿酸(SUA)、血尿素氮(BUN)等指标。结果 两组的HDL-C、LDL-C指标比较均差异无统计学意义(P>0.05),观察组HbA1c、TC、TG、FIB等指标均高于对照组,差异有统计学意义(P<0.05)。糖尿病正常蛋白尿组、糖尿病肾病微量白蛋白尿组与糖尿病肾病大量白蛋白尿组的HbA1c、TC、TG、HDL-C、LDL-C等指标均无明显的变化,而3组的Scr、BUN、SUA、Cys C等水平随着白蛋白尿水平的增加而上升;糖尿病肾病微量白蛋白尿组与糖尿病肾病大量白蛋白尿组的IL-6、TNF-α等指标均比糖尿病正常蛋白尿组有所降低,而糖尿病肾病微量白蛋白尿组IL-6、TNF-α等指标均比糖尿病肾病大量白蛋白尿组有所降低。两组的NEU%、WBC水平均差异无统计学意义(P>0.05),观察组的LP-PLA2、IL-1β、IL-6、CRP、TNF-α等指标均高于对照组,差异有统计学意义(P<0.05)。结论 糖尿病肾病患者血清炎症因子会有所上升,而且还会随着疾病的进展而加重,因此,血清炎症因子可作为评估糖尿病肾病的发病风险、病情的进展提供有利的依据。Objective To investigate the detection and evaluation of serum inflammatory factors in different stages of diabetic nephropathy.Methods From February 2019 to March 2021,a total of 100 patients with diabetic nephropathy admitted to the hospital,and they were included in the observation group.At the same time,100 healthy subjects who underwent physical examination during the same period were included in the control group.Two groups were detected:lipoprotein-associated phospholipase A2(LP-PLA2),interleukin-1β(IL-1β),interleukin-6(IL-6),serum C-reactive protein(CRP),tumor necrosis factor(TNF-a),serum inflammatory factors such as serum cystatin C(Cys C),neutrophil percentage(NEU%) and white blood cell count(WBC),the two groups of glycated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),fibrinogen(FIB),high-density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C) were detected at the same time and urine microalbumin(ALB),serum creatinine(Scr),serum uric acid(SUA),blood urea nitrogen(BUN) and other indicators.Results There was no statistically significant difference in HDL-C and LDL-C between the two groups(P>0.05).HbA1c,TC,TG,FIB and other indicators in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).There were no statistically significant changes in HbA1c,TC,TG,HDL-C,LDL-C and other indicators in the diabetic normoalbuminuria group,the diabetic nephropathy microalbuminuria group and the diabetic nephropathy macroalbuminuria group.The levels of Scr,BUN,SUA and Cys C in the three groups increased with the increase of albuminuria.The indexes of IL-6 and TNF-α in the diabetic nephropathy microalbuminuria group and the diabetic nephropathy macroalbuminuria group were lower than those in the diabetic normoalbuminuria group.The indexes of IL-6 and TNF-α in the diabetic nephropathy microalbuminuria group were lower than those in the diabetic nephropathy macroalbuminuria group.There was no statistically significant

关 键 词：糖尿病肾病 不同进展阶段 血清炎症因子 检测 

分 类 号：R587.2[医药卫生—内分泌]