尿清蛋白/尿肌酐水平检测对早期糖尿病肾病辅助诊断的应用价值  

Application Value of Urine Albumin/Urine Creatinine Level Detection in Auxiliary Diagnosis of Early Diabetic Nephropathy

作　　者：卢方 杨思思 LU Fang;YANG Sisi(School of Medicine,Xinxiang University,Xinxiang,Henan Province,453000 China)

机构地区：[1]新乡学院医学院,河南新乡453000

出　　处：《系统医学》2022年第5期76-78,119,共4页Systems Medicine

摘　　要：目的 研究尿清蛋白/尿肌酐水平检测对早期糖尿病肾病患者辅助诊断的应用价值。方法 选择2018年7月—2020年7月新乡市第一人民医院收治的50例糖尿病肾病患者,将其作为观察组,选择同期来该院健康体检的50名健康人群,将其作为对照组,比较两组人员的尿清蛋白/尿肌酐的比值;相关诊断指标[胱抑素C(CysC)、淀粉样蛋白A(AA)、血肌酐(Scr)、尿素氮(BUN)];研究尿清蛋白/尿肌酐和血清CysC以及AA之间的相关性。结果 观察组患者尿清蛋白/尿肌酐的比值为(39.70±5.17)mg/g,对照组尿清蛋白/尿肌酐的比值为(11.02±1.83)mg/g,两组比较差异有统计学意义(t=36.978,P<0.05)。观察组患者的CysC、AA高于对照组,差异有统计学意义(P<0.05);两组Scr、BUN比较,差异无统计学意义(P>0.05)。通过Pearson检验分析,糖尿病肾病患者的尿清蛋白/尿肌酐的比值和血清CysC、AA呈正相关性(P<0.05)。结论 糖尿病肾病患者在早期诊断中,通过检测尿清蛋白/尿肌酐的比值,能够发现患者尿清蛋白/尿肌酐的比值更高,且血清CysC以及AA会变得更低,临床中,可以将尿清蛋白/尿肌酐比值作为糖尿病肾病的早期辅助诊断指标,应用价值较高,值得推广。Objective To study the application value of urine albumin/urine creatinine level detection in auxiliary diagnosis of patients with early diabetic nephropathy.Methods Selected 50 patients with diabetic nephropathy admitted to Xixiang First People`s Hospital from July 2018 to July 2020.As the observation group,50 healthy people who came to the hospital for physical examination during the same period were selected as the control group.The ratio of urinary albumin/urine creatinine was compared between the two groups.Relevant diagnostic indicators [cystatin C(CysC),amyloid A(AA),serum creatinine(Scr),urea nitrogen(BUN)].To investigate the correlation between urinary albumin/urine creatinine and serum CysC and AA.Results The ratio of urinary albumin/urine creatinine in the observation group was(39.70±5.17) mg/g,and the ratio of urinary albumin/urine creatinine in the control group was(11.02±1.83) mg/g,the difference was statistically significant between the two groups(t=36.978,P<0.05).The CysC and AA of the observation group were higher than those of the control group,the difference was statistically significant(P<0.05),and the Scr and BUN of the two groups were compared,the difference was not statistically significant(P>0.05).Through Pearson test analysis,the ratio of urinary albumin/urine creatinine in patients with diabetic nephropathy has a close relationship with serum CysC and AA,which was a positive correlation(P<0.05).Conclusion In the early diagnosis of patients with diabetic nephropathy,the ratio of urine albumin/creatinine can be found to be higher by detecting the ratio of urine albumin/creatinine.And serum CysC and AA will become lower.In clinical practice,the ratio of urinary albumin/urine creatinine can be used as an early auxiliary diagnostic index for diabetic nephropathy,which has high application value and is worthy of promotion.

关 键 词：尿清蛋白 尿肌酐 糖尿病肾病 诊断价值 

分 类 号：R4[医药卫生—临床医学]