四联疗法与传统三联疗法治疗幽门螺杆菌感染胃炎的疗效比较  

Comparison of the Efficacy of Quadruple Therapy and Traditional Triple Therapy in the Treatment of Helicobacter Pylori-infected Gastritis

作　　者：卞艳青 BIAN Yanqing(Department of Gastroenterology,First People's Hospital of Sihong County,Suqian,Jiangsu Province,223900 China)

机构地区：[1]江苏省宿迁市泗洪县第一人民医院消化内科,江苏宿迁223900

出　　处：《中外医疗》2022年第9期110-113,共4页China & Foreign Medical Treatment

摘　　要：目的比较四联疗法与传统三联疗法治疗幽门螺杆菌(Hp)感染胃炎的效果。方法将该院2018年1月—2021年11月治疗的HP感染胃炎患者中方便选取70例进行全面分析,应用随机分组法分为治疗组、对照组,各组纳入35例后予以不同措施进行研究。对照组应用传统三联疗法,治疗组应用四联疗法,比较各组治疗情况。结果治疗组不良反应发生率为5.71%,显著较对照组的22.86%低,差异有统计学意义(χ^(2)=4.200,P=0.040);治疗组IL-6、TNF-α、hs-CRP水平均明显较对照组低,差异有统计学意义(t=3.258、2.074、3.566,P<0.05);治疗组Hp清除率为97.14%,显著较对照组(77.14%)高,差异有统计学意义(χ^(2)=4.590,P=0.032);治疗组临床总有效率为97.14%,明显较对照组的77.14%高,差异有统计学意义(χ^(2)=4.590,P=0.032)。结论在HP感染胃炎中,四联疗法效果显著优于传统三联疗法,临床用药价值理想。Objective To compare the effects of quadruple therapy and traditional triple therapy in the treatment of Helicobacter pylori(Hp)gastritis.Methods Seventy patients with HP-infected gastritis treated in the hospital from January 2018 to November 2021 were conveniently selected for comprehensive analysis.The patients were divided into a treatment group and a control group by random grouping,and 35 cases were included in each group and studied with different measures.The control group was given traditional triple therapy,and the treatment group was given quadruple therapy.The treatment conditions of each group were compared.Results The incidence of adverse reactions in the treatment group was 5.71%,which was significantly lower than that in the control group(22.86%),the difference was statistically significant(χ^(2)=4.200,P=0.040);the levels of IL-6,TNF-αand hs-CRP in the treatment group were significantly lower than those in the control group,the difference was statistically significant(t=3.258,2.074,3.566,P<0.05);the Hp clearance rate in the treatment group was 97.14%,which was significantly higher than that in the control group(77.14%),the difference was statistically significant(χ^(2)=4.590,P=0.032);the total clinical effective rate in the treatment group was 97.14%,which was significantly higher than that in the control group(77.14%),the difference was statistically significant(χ^(2)=4.590,P=0.032).Conclusion The effect of quadruple therapy is significantly better than that of traditional triple therapy in HP-infected gastritis,and its clinical value is ideal.

关 键 词：四联疗法 传统三联疗法 幽门螺杆菌感染胃炎 疗效 

分 类 号：R4[医药卫生—临床医学]