右美托咪定联合盐酸艾司氯胺酮对小儿短小手术后麻醉恢复期痛觉过敏及苏醒躁动的影响  

Effects of Dexmedetomidine Combined with Esketamine Hydrochloride on Hyperalgesia and Agitation during Anesthesia Recovery in Children after Short Surgery

作　　者：吕新[1] LYU Xin(Department of Anesthesiology,Peixian People's Hospital,Peixian,Jiangsu Province,221600 China)

机构地区：[1]沛县人民医院麻醉科,江苏沛县221600

出　　处：《中外医疗》2022年第11期88-91,共4页China & Foreign Medical Treatment

摘　　要：目的探讨右美托咪定联合盐酸艾司氯胺酮对小儿短小手术后麻醉恢复期痛觉过敏及苏醒躁动的影响。方法简单随机选取2020年1月—2021年8月在该院进行短小手术治疗的患儿80例,按照抽签法随机分为对照组、研究组,各40例。对照组患儿给予盐酸艾司氯胺酮麻醉,研究组患儿给予右美托咪定与盐酸艾司氯胺酮联合麻醉,对比两组患儿心率、平均动脉压、血氧饱和度、疼痛程度、苏醒躁动发生情况。结果术前,两组心率、平均动脉压、血氧饱和度比较,差异无统计学意义(P>0.05);术后,研究组心率、平均动脉压水平分别为(98.96±5.21)次/min、(90.24±8.13)mmHg,明显低于对照组,差异有统计意义(t=17.937、4.173,P<0.05),两组血氧饱和度对比,差异无统计学意义(P>0.05)。研究组术后3、5、8 h疼痛评分分别为(2.24±0.32)分、(1.69±0.22)分、(1.20±0.03)分,明显低于对照组,差异有统计学差异(t=20.065、14.309、4.002,P<0.05)。研究组苏醒躁动发生率为2.50%,明显低于对照组,差异有统计学意义(χ^(2)=4.507,P<0.05)。结论小儿短小手术治疗中应用右美托咪定与盐酸艾司氯胺酮联合麻醉的效果更加确切,不仅可以稳定患儿心率与血压水平,还可以减轻患儿疼痛程度,减少苏醒躁动的发生,临床应用价值非常高。Objective To investigate the effect of dexmedetomidine combined with esketamine hydrochloride on hyperalgesia and agitation during anesthesia recovery period in children after short surgery.Methods From January 2020 to August 2021,simply randomly selected 80 children who underwent short surgery in the hospital and were randomly divided into control group and study group according to the lottery method,with 40 cases in each group.The children in the control group were given esketamine hydrochloride anesthesia,and the children in the study group were given combined anesthesia with dexmedetomidine and esketamine hydrochloride.The heart rate,mean arterial pressure,blood oxygen saturation,pain degree,and the occurrence of agitation on awakening were compared between the two groups.Results Before surgery,there was no statistically significant difference in heart rate,mean arterial pressure and blood oxygen saturation between the two groups(P>0.05).After operation,the heart rate and mean arterial pressure in the study group were(98.96±5.21)beats/min and(90.24±8.13)mmHg,which were significantly lower than those in the control group,the difference was statistically significant(t=17.937,4.173,P<0.05),there was no statistically significant difference in blood oxygen saturation between the two groups(P>0.05).The pain scores of the study group at 3 h,5 h,and 8 h after operation were(2.24±0.32)points,(1.69±0.22)points,and(1.20±0.03)points,respectively,which were significantly lower than those in the control group,the difference was statistically significant(t=20.065,14.309,4.002,P<0.05).The incidence of awakening agitation in the study group was 2.50%,which was significantly lower than that in the control group,the difference was statistically significant(χ^(2)=4.507,P<0.05).Conclusion The effect of combined anesthesia with dexmedetomidine and esketamine hydrochloride in the treatment of children's short surgery is more accurate.It can not only stabilize the heart rate and blood pressure of the children,but also reduce t

关 键 词：小儿短小手术 右美托咪定 盐酸艾司氯胺酮 麻醉恢复期 痛觉过敏 苏醒躁动 

分 类 号：R563[医药卫生—呼吸系统]