紫癜性肾炎与IgA肾病发病机制的异同  

Similarities and differences in the pathogenesis of Henoch-Schönlein nephritis and IgA nephropathy

作　　者：刘京祺(综述) 吴小川(审校)[1] Liu Jingqi;Wu Xiaochuan(The Children′s Medical Center,the Second Xiangya Hospital of Central South University,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院儿童医学中心,长沙410011

出　　处：《国际儿科学杂志》2022年第4期231-235,共5页International Journal of Pediatrics

基　　金：科技部重点研发项目(2021YFC2702004)。

摘　　要：IgA血管炎是儿童时期常见的IgA介导的自身免疫性疾病,可累及多个系统,紫癜性肾炎(Henoch-Schönlein purpura nephritis,HSPN)是其主要并发症之一。HSPN与IgA肾病(IgA nephropathy,IgAN)均为儿童常见的肾小球炎症,但前者为最常见的继发性肾炎,后者为原发性肾炎中最迁延疾病之一,临床表型和预后存在差异。该文综述了国内外的相关文献,总结了HSPN和IgAN发病机制的异同,从而更好地理解这两种疾病。IgA vasculitis is a common autoimmune disease mediated by IgA in childhood,which can involve many systems.Henoch-Schönlein purpura nephritis(HSPN)is one of the main complications.Both HSPN and IgA nephropathy(IgAN)are common glomerulonephritis in children,but the former is the most common secondary glomerulonephritis and the latter is one of the most persistent diseases in primary glomerulonephritis.There are differences in clinical phenotype and prognosis.This article reviews the relevant literature,and summarizes the similarities and differences in the pathogenesis of HSPN and IgAN,so as to better understand the two diseases.

关 键 词：IGA肾病 紫癜性肾炎 发病机制 IGA1 

分 类 号：R72[医药卫生—儿科]