利奈唑胺致黑舌一例  

Black tongue induced by Linezolid:a case report

作　　者：程前 钟超 林海洋 于丽娟 罗少华[3] 梁瑶 CHENG Qian;ZHONG Chao;LIN Hai-yang;YU Li-juan;LUO Shao-hua;LIANG Yao(School of Life Sciences and Biopharmaceuticals,Shenyang Pharmaceutical University,Shenyang 110016,China;Department of Pharmacy,Shenzhen Hospital,University of Chinese Academy of Science,Guangdong Shenzhen 518106,China;Department of Pulmonary and Critical Care Medicine,Guangdong Provincial People's Hospital,Guangzhou 510080,China)

机构地区：[1]沈阳药科大学生命科学与生物制药学院,沈阳110016 [2]中国科学院大学深圳医院药学部,深圳518106 [3]广东省人民医院呼吸与危重症医学科,广州510080

出　　处：《临床药物治疗杂志》2022年第5期75-77,共3页Clinical Medication Journal

摘　　要：1例55岁男性因肺部感染、痰培养耐甲氧西林金黄色葡萄球菌(MRSA)使用利奈唑胺抗感染治疗。用药7 d后,患者舌苔变黑,考虑为利奈唑胺所致不良反应,故停用。停药10 d后患者舌苔颜色明显变浅,18 d后完全恢复正常。本文报告了利奈唑胺致黑舌这一少见不良反应,并结合文献对其发生机制进行探讨,以提高临床对这类不良反应的认识,促进利奈唑胺在临床安全使用。A 55-year-old man with pulmonary infection was treated with Linezolid because his sputum culture was methicillin-resistant Staphylococcus aureus(MRSA).7 days after the use of Linezolid,the patient’s tongue turned black,which was considered as an adverse drug reaction,so Linezolid was discontinued.Ten days after drug withdrawal,the color of the patient’s tongue coating became significantly lighter,and 18 days later,it completely returned to normal.In this paper,this rare adverse drug reaction(ADR)induced by Linezolid was reported,and its mechanism was discussed based on the literature,so as to improve the clinical understanding of such adverse reaction and promote the safe use of Linezolid in clinical practice.

关 键 词：利奈唑胺 黑舌 药物不良反应 

分 类 号：R969.3[医药卫生—药理学]