地拉罗司致患儿肾小管损害一例  

Deferasirox-induced renal tubular abnormalities in paediatric patient:a case report

作　　者：刘星星 李宇红 李悦 LIU Xing-Xing;LI Yu-hong;LI-Yue(Department of Pharmacy,Guiyang Maternal and Child Health Care Hospital,Guiyang Children's Hospital,Guiyang 550003,China;Department of Nephrology,Guiyang Maternal and Child Health Care Hospital,Guiyang Children's Hospital,Guiyang 550003,China)

机构地区：[1]贵阳市妇幼保健院/贵阳市儿童医院药学部,贵阳550003 [2]贵阳市妇幼保健院/贵阳市儿童医院肾内科,贵阳550003

出　　处：《临床药物治疗杂志》2022年第5期87-89,共3页Clinical Medication Journal

摘　　要：1例9岁男性患儿因患β-地中海贫血(重型)8年余长期输血治疗,由于输血导致铁负荷过载使用口服地拉罗司分散片,开始服用时肾功能未见异常。5年后,因尿检异常予加用百令胶囊治疗。1年5个月后再次出现尿常规检查异常,考虑地拉罗司所致的肾小管损害。停用该药,继续予口服百令胶囊2粒,每日1次。约2周后,患儿尿常规、尿微量蛋白系列指标改善。提示临床医师和药师应提高对地拉罗司造成肾小管损害的认识。In this paper,we report a 9-year-old male patient with beta-thalassemia major has been treated with long-term blood transfusion for more than 8 years.Due to iron overload,the child took Deferasirox Dispersible Tablets(Deferasirox).Five years later,as a result of abnormal urine test,the child was given Bailing Jiaonang.After one year and five months later,because of the abnormal urine test,we considered renal tubular abnormalities were induced by Deferasirox for this child and stopped it.Bailing Jiaonang was given two capsules,once daily.About two weeks later,the series of urine microprotein and urinalysis of this child were improved.It is suggested clinicians and pharmacists should improve their understanding of renal tubular damage caused by Deferasirox.

关 键 词：地拉罗司 肾小管损害 铁负荷过载 儿童 铁螯合剂 

分 类 号：R969.3[医药卫生—药理学] R556[医药卫生—药学]