食管癌围术期免疫检查点抑制剂致肺损伤二例  

Lung injury caused by perioperative immune checkpoint inhibitors in esophageal cancer:two case report

作　　者：滕湘楠 廖静 伍加利 徐珊玲 TENG Xiang-nan;LIAO Jing;WU Jia-li;XU Shan-ling(Department of Critical Care Medicine»the Affiliated Cancer Hospital,School of Medicine>University of Electronic Science and Technology of China»Chengdu 610042,China;Department of Respiratory and Critical Care Medicine»the Affiliated Hospital of Southwest Medical University»Sichuan Luzhou 646000,China)

机构地区：[1]电子科技大学医学院附属肿瘤医院四川省肿瘤医院重症医学科,成都610042 [2]西南医科大学附属医院呼吸危重症医学科,四川泸州646000

出　　处：《临床药物治疗杂志》2022年第5期90-92,共3页Clinical Medication Journal

摘　　要：免疫治疗被认为是针对各种类型癌症的较为有效的治疗策略,也已成为食管癌治疗的主要手段。本文分析2例食管癌术后的患者,使用免疫检查点抑制剂后出现免疫相关肺炎,经对症治疗后出现不同的结局,结合文献进行讨论,提示临床应用免疫检查点抑制剂时,应警惕肺部反应,早诊断,早治疗,以期能改善患者预后。Immunotherapy has been regarded as a relatively effective therapeutic strategy for various types of cancer and has become the main means for the treatment of esophageal cancer.In this paper,analyzed two cases of patients with postoperative esophageal cancer who developed immune-associated pneumonia after the use of immunosuppressants and had different outcomes after symptomatic treatment.Combining with literature discussion,it is suggested that clinicians should be vigilant of pulmonary reactins during application of immunosupressants,and early diagnosis and early treatment,are necessary to improve the prognosis of patients.

关 键 词：帕博利珠单抗 卡瑞利珠单抗 食管癌围术期 免疫相关肺炎 

分 类 号：R969.3[医药卫生—药理学] R973.9[医药卫生—药学]