磁性微球在天然药物化学中的应用进展  

Advances of magnetic microsphere in natural product chemistry

作　　者：张鹏[1] 王蒙[1] 丁彩桐 王知斌[1] 匡海学[1] ZHANG Peng;WANG Meng;DING Cai-tong;WANG Zhi-bin;KUANG Hai-xue(Heilongjiang University of Chinese Medicine,Key Laboratory of Basic and Applied Research in North Medicine,Ministry of Education,Heilongjiang Key Laboratory of Drug Efficacy Study Material of Traditional Chinese Medicine and Natural Product,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学教育部北药基础与应用研究重点实验室黑龙江省中药及天然药物药效物质基础研究重点实验室,黑龙江哈尔滨150040

出　　处：《化学工程师》2022年第5期54-56,95,共4页Chemical Engineer

基　　金：国家自然科学基金项目(81803686);国家自然科学基金配套项目(2018PP01);教育部"春晖计划"合作科研项目(HLJ2019035);黑龙江省普通本科高等学校青年创新人才培养计划(UNPYSCT-2020225);黑龙江省博士后专项经费资助(LBH-Q20180);黑龙江省“头雁”团队。

摘　　要：伴随化工合成与材料学的飞速发展,磁性微球这种新型材料与天然药物化学之间的学科交叉已经逐渐深入,磁性微球成功解决了部分以往依靠传统技术手段在天然药物化学研究中无法攻克的困难。它所应用的范围现已贯穿药物开发,成分分析,质量标准和制剂工艺等重要环节。本文主要围绕其在提取分离、活性筛选、化学分析和药物制剂4个方面的应用与进展进行综述,为相关研究提供参考依据。With the rapid development of chemical synthesis and materials science,the interdisciplinary between the new material magnetic microspheres and natural medicinal chemistry has gradually deepened.Magnetic microspheres have successfully solved some difficulties that cannot be overcome in the study of natural medicinal chemistry by traditional technical means.Its application scope has now run through important links such as drug development,component analysis,quality standards and preparation process.In this paper,the application and progress in four aspects of extraction and separation,activity screening,chemical analysis and pharmaceutical preparations were reviewed to provide reference for related experimental studies.

关 键 词：磁性微球 天然药物化学 化学研究 活性筛选 药物制剂 

分 类 号：R932[医药卫生—生药学]