补肺宣肃汤联合二氧丙嗪治疗肺气虚型咳嗽变异性哮喘的临床效果分析  

The clinical effects of the Bufei Xuansu decoction plus dioxpromazine on the lung Qi-deficiency type cough variant asthma

作　　者：朱毅 ZHU Yi

机构地区：[1]厦门海沧朱毅中西医结合诊所,福建厦门361026

出　　处：《中医临床研究》2022年第8期84-87,共4页Clinical Journal Of Chinese Medicine

摘　　要：目的:探讨补肺宣肃汤联合二氧丙嗪治疗肺气虚型咳嗽变异性哮喘的临床效果。方法:选取2019年6月-2020年6月来厦门海沧朱毅中西医结合诊所治疗的肺气虚型咳嗽变异性哮喘患者86例,按随机数字表法将患者分为对照组和治疗组,每组43例。对照组患者给予二氧丙嗪治疗,治疗组患者在对照组治疗的基础上同时口服补肺宣肃汤,两组均治疗2周。比较两组患者肺功能、临床疗效、中医证候积分、气道反应性指标及血清炎症相关因子的变化。结果:治疗后,两组患者第1秒用力呼气容积(Forced Expiratory Volume in 1 Second,FEV;)、用力肺活量(Forced Vital Capacity,FVC)和呼气流量峰值(Peak Expiratory Flow,PEF)组内和组间均差异有统计学意义(P<0.05);治疗后两组患者的中医证候积分差异有统计学意义(P<0.05)。治疗组治疗总有效率显著高于对照组(P<0.05)。治疗后,两组患者的最低反应阈值(Minimum Response Threshold,Dmin)和传导率下降斜度(Slope of Decline in Conductivity,SGrs)与治疗前相比显著改善(P<0.05),且治疗组治疗后Dmin和SGrs的改善程度比对照组更显著(P<0.05)。治疗后,两组患者的炎性反应相关因子的水平均降低,且治疗组降低更显著(P<0.05)。结论:补肺宣肃汤联合二氧丙嗪治疗肺气虚型咳嗽变异性哮喘疗效显著,可明显改善患者的肺功能、中医证候,降低气道反应及炎性反应。Objective:To explore the clinical effects of the Bufei Xuansu decoction(补肺宣肃汤)plus dioxpromazine on the lung Qi-deficiency type cough variant asthma.Methods:86 cases from June 2019 to June 2020 were selected as the study subjects and were divided into the control group and the treatment group according to the random number table method,with 43 cases in each group.Patients in the control group were treated with dioxpromazine,and patients in the treatment group were treated with dioxpromazine plus the Bufei Xuansu decoction.Patients in both groups were treated for 2 weeks.Results:After treatment,there were significant differences within each group and between the groups in FEV1,FVC,and PEF of patients(P<0.05).There were also significant differences in TCM symptom scores between the two groups after treatment(P<0.05).The total efficiency in the treatment group was significantly higher than that in the control group(P<0.05).After treatment,the Dmin and SGrs in the two groups were significantly improved compared with before treatment(P<0.05),and the improvement degree of Dmin and SGrs in the treatment group was more significantly than the control group(P<0.05).After treatment,the levels of inflammation-related factors of patients in the two groups were decreased,and in the treatment group were decreased more significantly(P<0.05).Conclusion:The Bufei Xuansu decoction plus dioxpromazine is effective on the lung Qi-deficiency type cough variant asthma.It can significantly improve patients’lung function,ameliorate TCM symptom,and reduce airway reactions and inflammation.

关 键 词：补肺宣肃汤 二氧丙嗪 肺气虚型 咳嗽变异性哮喘 

分 类 号：R256.12[医药卫生—中医内科学]