兰索拉唑与中药联合治疗脾胃湿热型慢性糜烂性胃炎的效果分析  

Effect Analysis of Lansoprazole Combined with Traditional Chinese Medicine in the Treatment of Chronic Erosive Gastritis of Spleen-stomach Damp-heat Type

作　　者：陈才凤 CHEN Caifeng(Department of Pharmacy,the First Hospital of Longyan City,Longyan,Fujian Province,361000 China)

机构地区：[1]福建省龙岩市第一医院药剂科,福建龙岩361000

出　　处：《中外医疗》2022年第10期9-12,31,共5页China & Foreign Medical Treatment

摘　　要：目的评价兰索拉唑与中药联合治疗脾胃湿热型慢性糜烂性胃炎的效果。方法方便选取于2019年6月—2021年8月收治的脾胃湿热型慢性糜烂性胃炎患者90例展开调查,依据电脑随机分配法分组,每组45例,对照组接受兰索拉唑治疗,观察组接受兰索拉唑+中药治疗,对比两组治疗效果(总有效率和Hp转阴率)、中医证候积分(嗳气欲吐、大便稀溏、口苦舌干、胃脘不适)、血清炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、转化生长因子-β1(TGF-β1)]、胃功能指标[胃蛋白酶原Ⅰ(PG-Ⅰ)和胃蛋白酶原Ⅱ(PG-Ⅱ)]。结果观察组患者治疗后的总有效率(95.56%)和Hp转阴率(88.89%)均显著优于对照组(80.00%、71.11%),差异有统计学意义(χ^(2)=5.075、4.444,P<0.05);观察组患者治疗后的嗳气欲吐、大便稀溏、口苦舌干、胃脘不适等中证症候评分均显著低于对照组,差异有统计学意义(P<0.05);治疗前两组血清炎性因子和胃功能指标差异无统计学意义(P>0.05),治疗后观察组患者的IL-6、TNF-α、TGF-β1、PG-Ⅱ均低于对照组,PG-Ⅰ高于对照组,差异有统计学意义(P<0.05)。结论临床针对脾胃湿热型慢性糜烂性胃炎患者予以兰索拉唑联合中药汤剂治疗的疗效显著,对清除体内炎症水平,改善胃功能和缓解胃部症状具有积极作用,值得临床推广。Objective To evaluate the effect of lansoprazole combined with traditional Chinese medicine on chronic erosive gastritis of spleen-stomach damp-heat type.Methods 90 patients with chronic erosive gastritis of the spleen-stomach damp-heat type admitted from June 2019 to August 2021 were conveniently selected for investigation.According to the principle of computer random allocation,with 45 cases in each group.the control group received lansoprazole treatment,and the observation group received lansoprazole+traditional Chinese medicine treatment.The therapeutic effects(total effective rate and Hp negative conversion rate),TCM symptom scores(belching and vomiting,loose stools,dry mouth and tongue,and epigastric discomfort),serum inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),transforming growth factor-β1(TGF-β1)],gastric function indicators[pepsinogen Ⅰ(PG-Ⅰ)and pepsinogen Ⅱ(PG-Ⅱ)]were compared between the two groups.Results The total effective rate(95.56%)and Hp negative rate(88.89%)of the observation group after treatment were significantly better than those of the control group(80.00%,71.11%),the difference was statistically significant(χ^(2)=5.075,4.444,P<0.05).After treatment,the TCM symptom scores of patients in the observation group,such as belching and vomiting,loose stools,dry mouth and tongue,and epigastric discomfort were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in serum inflammatory factors and gastric function indexes between the two groups(P>0.05).After treatment,the levels of IL-6,TNF-α,TGF-β1 and PG-Ⅱ in the observation group were lower than those in the control group,the PG-Ⅰ was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The clinical efficacy of lansoprazole combined with traditional Chinese medicine decoction in the treatment of chronic erosive gastritis of sp

关 键 词：兰索拉唑 中药 脾胃湿热型 慢性糜烂性胃炎 

分 类 号：R5[医药卫生—内科学]