儿科麻醉中氯胺酮与丙泊酚的临床应用效果研究  

Clinical Effect of Ketamine and Propofol in Pediatric Anesthesia

作　　者：王倩[1] WANG Qian(Department of Anesthesiology,Shanxian Central Hospital,Shanxian,Shandong Province,274300 China)

机构地区：[1]单县中心医院麻醉科,山东单县274300

出　　处：《中外医疗》2022年第10期54-57,共4页China & Foreign Medical Treatment

摘　　要：目的探究氯胺酮与丙泊酚应用于儿科麻醉中的可行性。方法方便选取的2020年4月—2021年6月该院104例行麻醉手术患儿分为研究组(52例,应用氯胺酮联合丙泊酚麻醉)、对照组(52例,应用氯胺酮麻醉)。对比两组麻醉效果、各项生命体征变化、麻醉苏醒时间、不良反应。结果研究组总有效率(96.15%)高于对照组(82.69%),差异有统计学意义(χ^(2)=4.981,P<0.05);术前两组患儿各项生命体征指标比较,差异无统计学意义(P>0.05);对照组手术开始的HR(120.15±19.77)次/min、SBP(15.11±1.23)kPa、DBP(7.77±0.68)kPa,高于术前,差异有统计学意义(t=4.464、8.344、7.349,P<0.05);手术5 min的HR(118.14±14.46)次/min、SBP(15.81±1.69)kPa、DBP(7.91±0.88)kPa,高于术前,差异有统计学意义(t=4.760、9.413、7.262,P<0.05);手术10 min的HR(116.22±14.18)次/min、SBP(15.21±1.42)kPa、DBP(7.52±1.22)kPa,高于术前,差异有统计学意义(t=4.048、8.261、3.769,P<0.05);研究组仅在手术开始时的SBP(14.83±1.38)kPa高于术前(12.81±1.22)kPa,差异有统计学意义(t=7.908,P<0.05),HR与DBP较之于术前比较,差异无统计学意义(P>0.05);两组患儿SpO_(2)、RR术前、术后比较,差异无统计学意义(P>0.05);研究组麻醉苏醒时间(19.14±6.84)min,短于对照组(42.14±15.06)min,差异有统计学意义(t=10.027,P<0.05);研究组不良反应发生率(7.69%)低于对照组(23.08%),差异有统计学意义(χ^(2)=4.727,P<0.05)。结论手术患儿选用氯胺酮、丙泊酚联合麻醉的效果远优于单纯氯胺酮麻醉,可对患儿各项生命体征加以改善,且麻醉苏醒时间明显缩短,不良反应少。Objective To explore the feasibility of ketamine and propofol in pediatric anesthesia.Methods 104 children undergoing anesthesia in the hospital from April 2020 to June 2021 were conveniently selected divided into study group(52 cases,ketamine combined with propofol anesthesia)and control group(52 cases,ketamine anesthesia).The effects of anesthesia,changes of vital signs,recovery time and adverse reactions were compared between the two groups.Results The total effective rate of study group(96.15%)was higher than that of control group(82.69%),the difference was statistically significant(χ^(2)=4.981,P<0.05);there was no statistically significant difference in vital signs between the two groups before surgery(P>0.05);in the control group,HR(120.15±19.77)times/min,SBP(15.11±1.23)kPa,DBP(7.77±0.68)kPa at the beginning of operation were higher than those before operation,the difference was statistically significant(t=4.464,8.344,7.349,P<0.05);HR(118.14±14.46)times/min,SBP(15.81±1.69)kPa,DBP(7.91±0.88)kPa 5 min after operation were higher than those before operation,the difference was statistically significant(t=4.760,9.413,7.262,P<0.05);HR(116.22±14.18)times/min,SBP(15.21±1.42)kPa,DBP(7.52±1.22)kPa 10 min after operation were higher than those before operation,the difference was statistically significant(t=4.048,8.261,3.769,P<0.05);in the study group,SBP(14.83±1.38)kPa at the beginning of surgery was higher than that before surgery(12.81±1.22)kPa,the difference was statistically significant(t=7.908,P<0.05).There was no statistical significance in HR and DBP compared with that before surgery(P>0.05).There was no statistical significance in preoperative and postoperative comparison of SpO_(2) and RR between the two groups(P>0.05).The anesthesia recovery time of the study group(19.14±6.84)min was shorter than that of the control group(42.14±15.06)min,the difference was statistically significant(t=10.027,P<0.05);The incidence of adverse reactions in the study group(7.69%)was lower than that in the control gr

关 键 词：儿科麻醉 氯胺酮 丙泊酚 效果 

分 类 号：R726.1[医药卫生—儿科]