补中益气汤联合艾灸治疗恶性肿瘤化疗后脾虚证的临床观察与研究  

Clinical observation and research on treating spleen deficiency syndrome after chemotherapy for malignant tumor with the Buzhong Yiqi decoction plus moxibustion

作　　者：周艳好 ZHOU Yanhao

机构地区：[1]广东祈福医院,广东广州511495

出　　处：《中医临床研究》2022年第13期52-54,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的:补中益气汤联合艾灸治疗恶性肿瘤化疗后脾虚证的临床观察与研究。方法:选取广东祈福医院2019年7月-2020年7月收治的恶性肿瘤化疗患者78例,以随机数字表法分为参照组与观察组,两组均根据患者实际情况选择合适的化疗方案、疗程。观察组在化疗基础上加用补中益气汤、艾灸。记录两组近期疗效、治疗前后免疫功能指标变化情况、中医证候评分、健康状况、中期疗效等相关数据。结果:观察组近期治疗总有效率优于参照组,P<0.05;两组治疗前CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)检测值的差异无统计学意义,P>0.05,治疗后观察组CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平高于参照组,组间、组内数据的差异均具有统计学意义,P<0.05;治疗前,两组脾虚证候评分、卡氏评分比较,差异无统计学意义(P>0.05);治疗后,观察组脾虚证候评分低于参照组,且观察组有更高的卡氏评分,差异有统计学意义(P<0.05);观察组总生存率、无瘤生存率、无进展生存期终点事件概率均优于对照组,差异具有统计学意义,P<0.05。结论:恶性肿瘤化疗后,给予补中益气汤联合艾灸治疗有利于改善脾虚证,提高患者的生活质量,临床应用价值显著。Objective:Tolinical observatione and research the effects of the Buzhong Yiqi decoction(补中益气汤)plus moxibustion on spleen deficiency syndrome after chemotherapy for malignant tumors.Methods:78 patients with malignant tumors were divided into the reference group and the observation group by random number table method.The two groups selected appropriate chemotherapy regimens and courses of treatment according to the actual conditions of the patients.The observation group received the Buzhong Yiqi decoction plus moxibustion more.The short-term efficacy,changes in immune function indexes before and after treatment,TCM syndrome scores,health status,and mid-term efficacy in the two groups were recorded.Results:The total efficiency of recent treatment in the observation group was better than the recent treatment,P<0.05.There was significant difference in CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)detection values between the two groups,P>0.05.After treatment,the levels of CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)in the observation group were higher than those in the reference group,P<0.05 for data comparison between groups and within group.Before treatment,there was no significant difference between the groups in spleen deficiency syndrome score and Karnofsky score(P>0.05).After treatment,the spleen deficiency syndrome score in the observation group was lower than the reference group,and the observation group had a higher Karnofsky score,and the difference was statistically significant(P<0.05).The overall survival rate,the disease-free survival rate and the probability of the endpoint of progression-free survival in the observation group were better those in the control group,and the difference was statistically significant,P<0.05.Conclusion:After chemotherapy for malignant tumor,the Buzhong Yiqi decoction plus moxibustion is beneficial to improve spleen deficiency syndrome,improve the life quality of patients,and has significantly clinical application value.

关 键 词：脾虚证 补中益气汤 艾灸 生活质量 

分 类 号：R273[医药卫生—中西医结合]