带状突触改变相关性耳聋的研究进展  

Progress of Research on Deafness Associated with Ribbon Synaptic Changes

作　　者：张艳芳[1] 郭玉芬[1] 徐百成[1] ZHANG Yanfang;GUO Yufen;XU Baicheng(Department of Otolaryngology,Lanzhou University Second Hospital,Lanzhou 730030)

机构地区：[1]兰州大学第二医院耳鼻咽喉头颈外科,兰州730030

出　　处：《中华耳科学杂志》2022年第3期467-470,共4页Chinese Journal of Otology

基　　金：国家自然科学基金地区基金项目(甘肃省特有少数民族遗传性耳聋家系分子病因学及功能研究,31960132);甘肃省卫生行业计划项目(人工耳蜗植入手术对前庭功能的影响研究,20JR10RA747)。

摘　　要：在听觉系统中,带状突触是位于内毛细胞和螺旋神经节神经元之间的囊泡相关的电子致密体结构,内毛细胞通过带状突触将神经递质释放到螺旋神经节,是形成听觉的基础。带状突触的结构及功能发生变化导致内毛细胞及螺旋神经之间突触传递异常,称为突触病变。近年来针对带状突触与耳聋的研究是一个热点,研究发现诸多因素都可能导致耳蜗突触病变,对内毛细胞带状突触的进一步研究有利于寻找听觉再生和保护的靶点。In the auditory system,the ribbon synapse is a vesicle-related electronically dense structure located between inner hair cells and spiral ganglion neurons.Inner hair cells release neurotransmitters to spiral ganglion through ribbon synapses,which is the basis for hearing formation,Changes in the structure and function of ribbon synapses lead to abnormal synaptic transmission between inner hair cells and spiral nerves,which is called synaptic lesion.In recent years,research on ribbon synapses and deafness is a hot spot.It has been found that many factors may lead to synaptic lesions.Further study of ribbon synapses in inner hair cells may help identify new targets for auditory regeneration and protection.

关 键 词：带状突触 内毛细胞 耳蜗突触病变 

分 类 号：R764[医药卫生—耳鼻咽喉科]