应用基因共表达网络分析在系统性红斑狼疮中鉴定中性粒细胞浸润相关生物标志物  

Identification of biomarkers related to neutrophils infiltration with gene co-expression network in systemic lupus erythematosus

作　　者：李慧娟[1] 马向波 袁立平[1] 徐雪阳 刘德林[1] 项丹丹 刘小红 王俊霞[1] LI Huijuan;MA Xiangbo;YUAN Liping;XU Xueyang;LIU Delin;XIANG Dandan;LIU Xiaohong;WANG Junxia(Department of Rheumatology and Immunology,Handan First Hospital,Handan Hebei 056000,China)

机构地区：[1]邯郸市第一医院风湿免疫科,河北邯郸056000

出　　处：《临床与病理杂志》2022年第5期1036-1046,共11页Journal of Clinical and Pathological Research

摘　　要：目的:系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种临床表现多样、累及多个器官的自身免疫性疾病。本研究试图识别中性粒细胞相关的SLE生物标志物,为SLE的治疗和管理提供潜在的理论依据。方法:使用加权基因共表达网络分析来自基因表达汇编(Gene Expression Omnibus,GEO)数据库的SLE表达数据,并识别与中性粒细胞相关的模块。结果:鉴定出FPR1、SLC2A3、TLR2、TLR4、CXCR1、MMP25、MGAM和KLHL2共8个关键基因。8个关键基因与中性粒细胞高度相关,并且在SLE中的表达显著上调。结论:通过各种分析和验证,8个关键基因是SLE中与中性粒细胞浸润相关的潜在生物标志物,这为SLE免疫治疗提供了潜在的靶点。Objective:Systemic lupus erythematosus(SLE)is an autoimmune disease with a large variety of clinical manifestations and involving many organs.The purpose of this study was to attempt to identify neutrophil-related SLE biomarkers to provide a potential rationale for the treatment and management of SLE.Methods:Weighted gene co-expression network analysis was used to analyze SLE expression data from the Gene Expression Omnibus(GEO)database,and identify modules related to Neutrophils.Results:Eight key genes(FPR1,SLC2A3,TLR2,TLR4,CXCR1,MMP25,MGAM and KLHL2)were identified.Furthermore,8 key genes were highly correlated with neutrophils and were significantly upregulated in SLE.Conclusion:Through various analyses and confirmations,8 key genes are potential biomarkers associated with Neutrophils infiltration in SLE.It also provides a potential target for SLE immunotherapy.

关 键 词：系统性红斑狼疮 基因共表达网络分析 中性粒细胞浸润 生物标志物 

分 类 号：R593.241[医药卫生—内科学] Q811.4[医药卫生—临床医学]