新工艺制备止血环酸  

Preparation of Tranexamic Acid by New Process

作　　者：吴卫忠[1] 蒋燕华 Wu Weizhong;Jiang Yanhua(School of Petrochemical Engineering, Changzhou University, Jiangsu Changzhou 213164;Changzhou yincheng Pharmaceutical Co Ltd, Jiangsu Changzhou 213000)

机构地区：[1]常州大学石油化工学院,江苏常州213164 [2]常州寅盛药业有限公司,江苏常州213000

出　　处：《化工时刊》2022年第5期13-14,43,共3页Chemical Industry Times

摘　　要：本文采用一锅法制备止血环酸,将加氢和转位同时进行,提高了反应收率、缩短了反应时间、革除了氢氧化钡的使用,减少了对环境的影响。较好的反应条件是:氢氧化钠的浓度0.5~1.0%,氢氧化钠用量为0.12 mol,反应温度为170℃,反应时间14 h,此时,反应收率达到95.7%,反式体含量达99.7%。In this paper,hydrogenation and transposition are carried out simultaneously by one pot method,which improves the reaction yield,shortens the reaction time,eliminates the use of barium hydroxide and reduces the impact on the environment.The better reaction conditions are:the concentration of sodium hydroxide is 0.5~1.0%,the dosage of sodium hydroxide is 0.12 mol,the reaction temperature is 170℃,and the reaction time is 14 hours.The yield was 95.7%and the content of trans monomer was 99.7%.

关 键 词：止血环酸 一锅法 

分 类 号：TQ463[化学工程—制药化工]