Effect of ancient Khorasan wheat on gut microbiota,inflammation,and short-chain fatty acid production in patients with fibromyalgia  

作　　者：Simone Baldi Giuditta Pagliai Monica Dinu Leandro Di Gloria Giulia Nannini Lavinia Curini Marco Pallecchi Edda Russo Elena Niccolai Giovanna Danza Stefano Benedettelli Giovanna Ballerini Barbara Colombini Gianluca Bartolucci Matteo Ramazzotti Francesco Sofi Amedeo Amedei 

机构地区：[1]Department of Experimental and Clinical Medicine,University of Florence,Florence 50134,Italy [2]Unit of Clinical Nutrition,Careggi University Hospital,Florence 50134,Italy [3]Department of Neurosciences,Psychology,Drug Research and Child Health,Section of Pharmaceutical and Nutraceutical Sciences,University of Florence,Sesto Fiorentino 50019,Italy [4]Department of Biomedical,Experimental and Clinical Sciences“Mario Serio”,University of Florence,Florence 50134,Italy [5]Department of Agriculture,Food,Environment and Forestry,University of Florence,Florence 50144,Italy [6]Multidisciplinary Center for Pain Therapy,Reference Center for Fibromyalgia,Piero Palagi Hospital,USL Toscana Centro,Florence 50122,Italy [7]SOD of Interdisciplinary Internal Medicine,Careggi University Hospital,Florence 50134,Italy

出　　处：《World Journal of Gastroenterology》2022年第18期1965-1980,共16页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND Fibromyalgia(FM)syndrome is mainly characterized by widespread pain,sleeping disorders,fatigue,and cognitive dysfunction.In many cases,gastrointestinal distress is also reported,suggesting the potential pathogenic role of the gut microbiota(GM).The GM is deeply influenced by several environmental factors,especially the diet,and recent findings highlighted significant symptom improvement in FM patients following various nutritional interventions such as vegetarian diet,low-fermentable oligosaccharides,disaccharides,monosaccharides,and polyols based diets,gluten-free diet,and especially an ancient grain supplementation.In particular,a recent study reported that a replacement diet with ancient Khorasan wheat led to an overall improvement in symptom severity of FM patients.AIM To examine the effects of ancient Khorasan wheat on the GM,inflammation,and short-chain fatty acid production in FM patients.METHODS After a 2-wk run-in period,20 FM patients were enrolled in this randomized,double-blind crossover trial.In detail,they were assigned to consume either Khorasan or control wheat products for 8 wk and then,following an 8-wk washout period,crossed.Before and after treatments,GM characterization was performed by 16S rRNA sequencing while the fecal molecular inflammatory response and the short-chain fatty acids(SCFAs)were respectively determined with the Luminex MAGPIX detection system and a mass chromatography-mass spectrometry method.RESULTS The Khorasan wheat replacement diet,in comparison with the control wheat diet,had more positive effects on intestinal microbiota composition and on both the fecal immune and SCFAs profiles such as the significant increase of butyric acid levels(P=0.054),candidatus Saccharibacteria(P=9.95e-06)and Actinobacteria,and the reduction of Enterococcaceae(P=4.97e-04).Moreover,the improvement of various FM symptoms along with the variation of some gut bacteria after the Khorasan wheat diet have been documented;in fact we reported positive correlations between Actinobacteria and

关 键 词：Fibromialgya Gut microbiota Khorasan wheat Fibromialgya symptoms Ancient wheat 

分 类 号：R402[医药卫生—临床医学]