5-羟色胺能致幻剂:抑郁症治疗的新策略  

Serotonergic psychedelics:a novel treatment for depression

作　　者：赵香婷 杜英杰 刘爽[1] ZHAO Xiang-ting;DU Ying-jie;LIU Shuang(School of Basic Medicine,Jiamusi University,Jiamusi 154007,China;Department of Anesthesiology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)

机构地区：[1]黑龙江省佳木斯大学基础医学院,黑龙江佳木斯154000 [2]首都医科大学附属北京同仁医院麻醉科,北京100730

出　　处：《中国药理学与毒理学杂志》2022年第4期282-287,共6页Chinese Journal of Pharmacology and Toxicology

基　　金：黑龙江省教育厅基础研究项目(2019-KYYWF-1336)。

摘　　要：抑郁症已成为全球性的严重公共卫生问题,目前临床一线抗抑郁药物大多是基于经典“单胺假说”研发的,普遍存在起效延迟、有效率不高、损伤认知等缺陷。近年来,一些临床研究发现,5-羟色胺(5-HT)能致幻剂具有改善抑郁和创伤后应激障碍等精神类疾病的潜能。本文重点围绕5-HT能致幻剂对神经可塑性、炎症反应和神经递质水平的调节作用,综述了其抗抑郁的可能机制,为重度抑郁症的治疗提供新的选择。Depression has become a serious public health concern globally.Currently,most of the clinical antidepressants are developed based on the classical"monoamine hypothesis".These drugs generally have side effects,such as delayed onset,low efficiency and cognitive impairment.Outcomes of clinical research into serotonergic psychedelics show promise for addressing a wide range of serious mental disorders,including depression and post-traumatic stress disorder.Here,we focuse on the regu⁃lation of neuroplasticity,immunomodulation and modulation of neurotransmitters,and outline the antide⁃pressant mechanisms of serotonergic psychedelics in the hopes of substantiating a potential alterna⁃tive therapeutic strategy for major depression.

关 键 词：5-羟色胺能致幻剂 重度抑郁症 神经可塑性 免疫调节 神经递质 

分 类 号：R971[医药卫生—药品] R964[医药卫生—药学]