通过靶向自噬治疗动脉粥样硬化的天然产物研究进展  

Research progress in natural products of targeted autophagy in treatment of atherosclerosis

作　　者：范吉林 朱婷婷 田晓玲[2] 刘思佳 苏静[3] 张世亮[3] FAN Ji-lin;ZHU Ting-ting;TIAN Xiao-ling;LIU Si-jia;SU Jing;ZHANG Shi-liang(The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Neurosurgery,Affiliated Hospital of Binzhou Medical College,Binzhou 256600,China;Department of Cardiology,Affiliated Hospital,Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学第一临床医学院,山东济南250014 [2]滨州医学院附属医院神经外科,山东滨州256600 [3]山东中医药大学附属医院心内科,山东济南250014

出　　处：《中国药理学与毒理学杂志》2022年第4期288-296,共9页Chinese Journal of Pharmacology and Toxicology

基　　金：国家科技重大专项(2017ZX09301003)。

摘　　要：动脉粥样硬化(AS)是心血管疾病中常见的慢性炎症性疾病,是心肌梗死、心力衰竭和卒中等多种致命疾病的病理基础。自噬是一种保护性的细胞内过程,通过控制蛋白质质量起到保持细胞稳态作用。越来越多研究表明,自噬参与了AS及相关疾病的发生发展。天然产物,如槲皮素、山奈酚、姜黄素、丹参酚酸B和小檗碱等,具有靶向自噬治疗AS的潜力。本综述总结了天然产物靶向自噬治疗AS的分子机制,包括诱导内皮细胞自噬抑制炎症和氧化应激反应、促进巨噬细胞自噬抑制脂质积累以及诱导血管平滑肌细胞自噬,减少凋亡等,涉及信号通路主要包括磷脂酰肌醇-3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白信号通路、NF-κB信号通路、P38丝裂原活化蛋白激酶信号通路、c-Jun氨基端激酶信号通路和腺苷酸蛋白活化激酶/哺乳动物雷帕霉素靶蛋白/unc-51样自噬激活激酶1信号通路等,以期为AS治疗提供新的研究思路。The biological underpinning of many deadly diseases such as myocardial infarction,heart failure,and stroke is atherosclerosis(AS),a frequent chronic inflammatory condition in cardiovas⁃cular disorders.Autophagy is a protective intracellular mechanism that helps to maintain cell homeosta⁃sis by managing protein quality.Autophagy has been proved to be implicated in the occurrence and progression of AS and similar disorders by a growing number of studies.Furthermore,natural mole⁃cules derived from Chinese herbal medicines,such as quercetin,kaempferol,curcumin,salvianolic acid B,and berberine,have the potential of targeting autophagy in treating AS.The molecular mechanism by which natural products combat AS by targeting autophagy therapy for is summarized in this review,which involves stimulating endothelial cell autophagy to decrease inflammation and oxidative stress.The signal pathways involved include phosphatidylinositol-3-kinase/protein kinase B/mammalian target of Rapamycin,NF-κB,P38 mitogen-activated protein kinase,c-Jun N-terminal kinase,AMP-activated protein kinase/mammalian target of Rapamycin/Unc-51 like autophagy activating kinase 1 in order to help clinicians think along a new line for future treatment of AS.

关 键 词：动脉粥样硬化 自噬 天然产物 

分 类 号：R285[医药卫生—中药学] R972[医药卫生—中医学]