Emerging role of biosimilars in the clinical care of inflammatory bowel disease patients  

作　　者：Hala Najeeb Farah Yasmin Salim Surani 

机构地区：[1]Department of Internal Medicine,Dow University of Health Sciences,Karachi 74200,Pakistan [2]Department of Medicine,Texas A&M University,College Station,TX 77843,United States [3]Department of Anesthesiology,Mayo Clinic,Rochester,MN 55905,United States

出　　处：《World Journal of Clinical Cases》2022年第14期4327-4333,共7页世界临床病例杂志

摘　　要：The increasing incidence of inflammatory bowel disease(IBD)globally has redirected the healthcare system's focus towards safe and affordable pharmacological interventions.The inception of anti-tumor necrosis factor-α(TNF-α)had resulted in a trend shift from surgical interventions.However,as the patents of approved anti-TNF-αdrugs expire,biological copies of the many approved products are in the pipeline.The most commonly used biosimilar for IBD has been infliximab,followed by Adalimumab biosimilars which have been approved in major countries across the world.Although biosimilars are approved on the basis of similarity of their reference product,the lack of real-world evidence of its safety in ulcerative colitis and Crohn’s disease patients has contributed to physicians’hesitancy.However,biosimilars are expected to reduce treatment costs and provide economic benefits.

关 键 词：Inflammatory bowel disease BIOSIMILARS Anti-tumor necrosis factor INFLIXIMAB ADALIMUMAB Ulcerative colitis Chrons disease 

分 类 号：R473.5[医药卫生—护理学]