Serum-negative Sjogren's syndrome with minimal lesion nephropathy as the initial presentation:A case report  

作　　者：Chun-Yan Li Yi-Man Li Mei Tian 

机构地区：[1]Department of Rheumatology,Affiliated Hospital of Zunyi Medical University,Zunyi 563003,Guizhou Province,China [2]Department of Nephrology,Affiliated Hospital of Zunyi Medical University,Zunyi 563003,Guizhou Province,China

出　　处：《World Journal of Clinical Cases》2022年第14期4625-4631,共7页世界临床病例杂志

摘　　要：BACKGROUND Primary Sjogren's syndrome(pSS)is an autoimmune disease,and renal involvement has been considered to be one of the systemic complications of pSS.Patients who have sjogren's syndrome with renal disease as the first manifestation and no exocrine gland involvement or autoantibodies can be missed clinically.CASE SUMMARY We here in report an unusual case of a primary Sjogren's syndrome in a 43-yearold female who had minimal lesion nephropathy as the initial presentation,and the patient was negative for serum anti-SSA and anti-SSB antibodies and did not have signs of exocrine gland involvement.The patient’s Sjogren's syndrome was confirmed by a minor salivary gland biopsy(MSGB)and a filter paper test.the patient’s oedema subsided,and the patient’s urinary protein resolved,showing that the treatment was effective.CONCLUSION MSGB should be considered if pSS is suspected in patients who do not have the typical pSS symptoms or who are positive for the specific autoantibodies.

关 键 词：Sjogren's syndrome Anti-SSA Anti-SSB antibodies Minimal lesion nephropathy Minor salivary gland biopsy Case report 

分 类 号：R593.2[医药卫生—内科学]