流产组织染色体整倍性对同一取卵周期冻融胚胎移植妊娠结局的影响  

Effect of chromosome aneuploidy in abortion tissue on pregnancy outcome of frozen-thawed embryos transfer from same oocyte retrieval cycle

作　　者：赵伟娥 陈攀宇[1] 李玉洁[1] 贾磊[1] 梁晓燕[1] ZHAO Wei-e;CHEN Pan-yu;LI Yu-jie;JIA Lei;LIANG Xiao-yan(Sixth Affiliated Hospital of Sun Yat-sen University,Reproductive Medicine Research Center,Guangzhou 510000)

机构地区：[1]中山大学附属第六医院生殖医学研究中心,广州510000

出　　处：《生殖医学杂志》2022年第6期772-776,共5页Journal of Reproductive Medicine

基　　金：国家自然基金面上项目(82071713)。

摘　　要：目的分析流产组织染色体整倍性对同一取卵周期冻融胚胎移植(FET)妊娠结局的影响。方法回顾性分析2012年3月至2020年1月在中山大学附属第六医院行辅助生殖(ART)治疗后妊娠患者的临床资料,检测流产组织染色体核型,收集同一取卵周期有冷冻胚胎并行FET助孕患者的临床结局数据。根据流产组织染色体结果,分为整倍体组(206例患者,292个周期)和非整倍体组(174例患者,247个周期),比较两组患者的妊娠结局。结果整倍体组取卵时年龄显著低于非整倍体组年龄(P<0.05),AMH值显著高于非整倍体组(P<0.05);整倍体组的原发不孕比例和替代周期方案比例均显著高于非整倍体组(P<0.05);两组患者BMI、流产孕周、转换日E2水平与内膜厚度、平均移植胚胎数、优质胚胎数、平均移植周期数均无统计学差异(P>0.05)。整倍体组与非整倍体组的临床妊娠率、流产率、活产率与累积活产率均无统计学差异(P>0.05)。流产组织染色体结果与临床妊娠率及活产率均无显著相关(P>0.05)。取卵时年龄、移植胚胎数目是影响临床妊娠率及活产率的独立危险因素(P<0.05)。结论流产组织染色体核型结果并未影响来自同一取卵周期FET的临床妊娠率、流产率、活产率及累积活产率。Objective:To investigate effect of chromosome aneuploidy in abortion tissue on pregnancy outcome of frozen-thawed embryo transfer(FET)from the same oocyte retrieval cycle.Methods:The clinical data of pregnant patients treated with assisted reproduction(ART)in the Sixth Affiliated Hospital of Sun Yat-Sen University from March 2012 to January 2020 were retrospectively analyzed.The karyotype of abortion tissues was detected.The data of clinical outcome of patients who had frozen embryos from the same oocyte retrieval cycle and received FET assisted pregnancy were collected.They were divided into two groups according to the abortion tissue’chromosomal results:euploidy group(206 patients,292 cycles)and aneuploidy group(174 patients,247 cycles).Results:The age of patients when oocytes retrieval in euploidy group was significantly lower than that in aneuploidy group(P<0.001).AMH in euploidy group was significantly higher than that in aneuploidy group(P<0.001).The proportions of primary infertility and hormone replacement cycles in the aneuploid group were significantly higher than those in the aneuploid group(P<0.05).The age of patients when oocyte retrieval in the aneuploid group was significantly lower than that in the aneuploid group(P<0.001),and the AMH level was significantly higher than that in the aneuploid group(P<0.001).There were no significant differences in BMI,abortion gestational weeks,E2 level and endometrial thickness on conversion day,average number of embryos transferred,number of high-quality embryos and average number of transfer cycles between the two groups(P>0.05).There were no significant differences in clinical pregnancy rate,abortion rate,live birth rate and cumulative live birth rate between euploid group and aneuploid group(P>0.05).There was no significant correlation between the chromosome results of abortion tissue and clinical pregnancy rate and live birth rate(P>0.05).The age of patients when oocyte retrieval and the number of transferred embryos were independent risk factors affecting

关 键 词：染色体核型 非整倍体 稽留流产 

分 类 号：R711.6[医药卫生—妇产科学]