草酸钙结石形成过程中晶体-细胞相互作用的机制及影响因素  

Mechanism and influencing factors of crystal-cell interaction in the formation of calcium oxalate stones

作　　者：邓志军 谭靖[1] 张锐 曾嘉 尹光明[1] 蒋先镇[1] DENG Zhijun;TAN Jing;ZHANG Rui;ZENG Jia;YIN Guangming;JIANG Xianzhen(Department of Urology,Third Xiangya Hospital,Central South University,Changsha 410013,China)

机构地区：[1]中南大学湘雅三医院泌尿外科,长沙410013

出　　处：《中南大学学报（医学版）》2022年第5期555-561,共7页Journal of Central South University ：Medical Science

基　　金：湖南省自然科学基金(2020JJ4848)。

摘　　要：肾结石是一种病因复杂、发病率较高的疾病,其最常见的化学成分类型是草酸钙结石。草酸钙结石的形成过程包括结晶形成、晶体生长和聚集、晶体与肾小管上皮细胞相互作用、晶体入侵肾间质细胞外基质等,在这些过程中,晶体和肾小管上皮细胞的相互作用对于肾脏的晶体保留和肾结石形成非常重要。近年许多研究发现晶体和肾小管上皮细胞的相互作用与多种关键结合分子、肾小管上皮细胞内质网应激、细胞外基质蛋白及各类排石药物等关系密切。了解晶体-细胞相互作用的机制对草酸钙结石的预防和早期治疗具有重要意义。Kidney stone is a disease with complex etiology and high incidence,and the most common chemical composition type of it is calcium oxalate stone.The formation of calcium oxalate stones includes crystal formation,crystal growth and aggregation,crystal interaction with renal tubular epithelial cells,and crystal invasion of renal interstitial extracellular matrix and so on.In these processes,crystal-cell interactions are essential for kidney crystal retention and kidney stone formation.Recently many studies have found that the interaction between crystal and renal tubular epithelial cells is closely related to various key binding molecules,endoplasmic reticulum stress of tubular cells,extracellular matrix proteins,and various lithotriptic drugs.Understanding the mechanism of crystal-cell interaction is of great significance for the prevention and early treatment of calcium oxalate stones.

关 键 词：草酸钙结石 肾小管上皮细胞 晶体 相互作用 

分 类 号：R692.4[医药卫生—泌尿科学]