A robust polyacrylic acid/chitosan cryogel for rapid hemostasis  

作　　者：SHI MingYue JIANG LiJie YU ChaoJie DONG XiaoRu YU QingYu YAO MengMeng HE ShaoShuai YUE ZhiWei YAO FangLian ZHANG Hong SUN Hong LI JunJie 

机构地区：[1]School of Chemical Engineering and Technology,Tianjin University,Tianjin,300350,China [2]School of Basic Medical Sciences,North China University of Science and Technology,Tangshan,063210,China [3]Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering,Ministry of Education,Tianjin University,Tianjin,300350,China

出　　处：《Science China(Technological Sciences)》2022年第5期1029-1042,共14页中国科学（技术科学英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.U20A20261,31870948,31971250,and 52073205);Natural Science Foundation of Tianjin(Grant No.20JCYBJC00660)。

摘　　要：Currently,it is a challenge to develop hemostatic materials with high water absorption capacity and anti-fatigue properties for quickly preventing massive hemorrhage from arteries and visceral organs.A series of polyacrylic acid/chitosan(PAA/CS)cryogels were prepared by a cryostructurization technique to improve mechanical performance and hemostatic efficiency of chitosan(CS).In this system,the chemically cross-linked PAA network was used as a framework to improve water absorption behaviors and mechanical strength.The CS network was co-blended by hydrogen bonding and electrostatic interactions,both of which synergistically promoted hemostasis.These cryogels had high porosity(>94%),rapid water absorption rate(<3 s),high blood absorption capacity(>2000%),outstanding mechanical strength,and fatigue resistance.Moreover,the results of cytotoxicity and hemolysis demonstrated that the cryogels had good biocompatibility.Notably,the PAA/CS cryogels exhibited superior whole blood coagulation ability and red blood cell and platelet adhesion ability compared to those of commercial hemostatic dressing(gauze,gelatin sponges,and CS sponges).Based on these results,mouse femoral artery hemorrhage models and liver hemorrhage models were prepared to investigate the hemostatic ability of the prepared PAA/CS cryogels.Results suggested that the hemostatic ability of PAA5/CS cryogels was superior to that of commercial hemostatic materials.Therefore,the PAA/CS cryogels showed potential application in preventing massive hemorrhage from arteries and visceral organs.

关 键 词：hemostatic dressing CHITOSAN polyacrylic acid CRYOGEL 

分 类 号：TQ427.26[化学工程] R318.08[医药卫生—生物医学工程]