金银花化学成分的研究  

Chemical constituents from Lonicera japonica

作　　者：鲍学梅[1,2] 乔金为 左亚峰 BAO Xue-mei;QIAO Jin-wei;ZUO Ya-feng(Department of Pharmacy,The Second Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230061,China;Anhui Acupuncture Hospital,Hefei 230061,China;College of Pharmacy,Bozhou University,Bozhou 236800,China)

机构地区：[1]安徽中医药大学第二附属医院药学部,安徽合肥230061 [2]安徽省针灸医院,安徽合肥230061 [3]亳州学院药学院,安徽亳州236800

出　　处：《中成药》2022年第5期1501-1505,共5页Chinese Traditional Patent Medicine

基　　金：国家中医药管理局2015年全国中药特色技术传承人才培训项目(国中医药人教函[2015]168);安徽省高等学校自然科学研究重点项目(KJ2020A0765)。

摘　　要：目的研究金银花Lonicera japonica Thunb.的化学成分。方法采用硅胶、ODS柱色谱、制备高效液相色谱等方法对金银花70%乙醇提取物的化学成分进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到15个化合物,分别为腺嘌呤核苷(1)、cordysinin B(2)、鸟嘌呤核苷(3)、烟酰胺(4)、8-表金吉苷(5)、7-酮马钱素(6)、金吉苷(7)、supinaionodie B(8)、表断氧马钱子苷半缩醛内酯(9)、断氧马钱子苷半缩醛内酯(10)、獐牙菜苷(11)、secologanol(12)、1,2-O-didicaffeoyl-cychopenta-3-ol(13)、绿原酸(14)、紫丁香苷(15)。结论化合物2、4、13为首次从该植物中分离得到。AIM To study the chemical components from Lonicera japonica Thunb..METHODS The 70%ethanol extract from the flowers of L.japonica was isolated and purified by silica,ODS column chromatography,pre-HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Fifteen compounds were isolated and identified as adenosine(1),cordysinin B(2),guanosine(3),nicotiamide(4),8-epikingiside(5),ketologanin(6),kingiside(7),supinaionodie B(8),epi-vogeloside(9),vogeloside(10),sweroside(11),secologanol(12),1,2-O-didicaffeoyl-cychopenta-3-ol(13),chlorogenic acid(14),syringin(15).CONCLUSION Compounds 2,4,13 are isolated from this plant for the first time.

关 键 词：金银花 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]