核医学分子影像技术在外泌体活体示踪中的研究进展  

Advances in molecular-imaging techniques of nuclear medicine for tracing exosomes in vivo

作　　者：宁宇 冯贵生[2] 蔡敏[2] 李思进[3] Ning Yu;Feng Guisheng;Cai Min;Li Sijin(Major of Imaging Medicine and Nuclear Medicine,Medical Imaging College,Shanxi Medical University,Taiyuan 030001,China;Department of Nuclear Medicine,Shanxi Provincial People's Hospital&the Fifth Hospital of Shanxi Medical University,Taiyuan 030012,China;Department of Nuclear Medicine,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学医学影像学院影像医学与核医学专业,太原030001 [2]山西省人民医院(山西医科大学第五医院)核医学科,太原030012 [3]山西医科大学第一医院核医学科,太原030001

出　　处：《国际放射医学核医学杂志》2022年第1期47-52,共6页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：中国博士后科学基金(2020M670704);山西省基础研究计划项目(202103021224377)。

摘　　要：外泌体是参与细胞间信号传导的重要物质,具有很高的生物学价值,目前已成为研究热点。高特异性、高灵敏度的外泌体示踪方法是揭示外泌体生物学功能的关键。外泌体示踪主要依靠分子影像学技术,其优势主要集中在核医学分子显像,其中包括外泌体的核素直接标记法和间接标记法。核医学分子显像可与解剖学成像相结合,定量监测外泌体的分布,还可对外泌体治疗的效果进行评价,在外泌体示踪研究中发挥着极其重要的作用。笔者将从外泌体的生物学价值、核医学分子影像技术在外泌体示踪中的研究进展作一综述。Exosomes are important substances involved in intercellular signal transduction and have high biological values.Accordingly,exosomes have become a research hotspot.Highly specific and sensitive exosome-tracing method is the key to revealing the biological function of exosomes.Exosome tracing relies mostly on molecular imaging and its advantages focus primarily on nuclear-medicine molecular imaging,which includes direct and indirect radionuclide-labeling methods.Nuclear-medicine molecular imaging could be combined with anatomical imaging to quantitatively monitor exosome distribution and could be used to evaluate the therapeutic effect of exosomes.It plays an extremely important role in exosome tracing.This paper reviews the biological value of exosomes and the research progress in tracing exosomes through nuclear-medicine molecular imaging.

关 键 词：外泌体 活体示踪 核医学 分子影像技术 

分 类 号：R817[医药卫生—影像医学与核医学]