多角度复合的超声多普勒矢量血流成像  

Blood flow image by multi-angle composite ultrasonic Doppler vector

作　　者：王康宇 周昱林 何丽媛[1] 卢春尧 于润 吴大伟[1] Wang Kang-Yu;Zhou Yu-Lin;He Li-Yuan;Lu Chun-Yao;Yu Run;Wu Da-Wei(State Key Laboratory of Mechanics and Control of Mechanical Structures,Nanjing University of Aeronautics and Astronautics,Nanjing 210016,China;Jinling Hospital,Medical School of Nanjing University,Nanjing 210093,China)

机构地区：[1]南京航空航天大学航空学院,机械结构力学及控制国家重点实验室,南京210016 [2]南京大学医学院,金陵医院,南京210093

出　　处：《物理学报》2022年第10期192-200,共9页Acta Physica Sinica

基　　金：国家重点研发计划(批准号:2019YFE0109300);南京航空航天大学研究生创新基地(实验室)开放基金项目(批准号:kfjj20200101)资助的课题。

摘　　要：血流速度的精确测量对于研究心血管疾病和动脉粥样硬化斑块的形成至关重要,传统的彩色多普勒方法局限于获得沿超声束的速度分量,难以描绘复杂的血流运动.本文提出了一种多角度复合的超声多普勒方法,结合多角度复合技术来提升速度估算的准确度.该方法可以获取复杂血管内较为精确的二维速度矢量,实现血管内动态矢量血流成像.仿真结果表明,多角度复合有效地减小了速度估算的误差,提升图像的质量.颈动脉分叉仿体成像实验表明,该方法可以获得较为清楚的血管内速度矢量图像.定量分析结果表明5个角度复合方案能够准确估算血管内流量.本文提出的多角度复合的矢量多普勒具有可视化复杂血流和计算血流动力学参数的能力,在矢量血流成像方法中有重要潜力.Precise measurement of blood flow is of vital importance in studying the formation of thrombus and atherosclerotic plaque.However,conventional color Doppler methods are limited to obtaining the velocity component along the ultrasound beam and have poor accuracy.Several Doppler flow imaging methods based on the plane wave emission can estimate the blood velocity vectors and visualize hemodynamic parameters,which provide more detailed blood flow information and effectively improve the capability of clinical diagnosis treatment.Considering the low accuracy of the Doppler flow methods for measuring velocity in complex flow fields,an optimization technique is used to improve the imaging quality and the accuracy of velocity estimation.In this study we propose a modified vector Doppler method through combining multi-angle compound technique,to reconstruct blood velocity vectors of carotid bifurcations obtained from 3D printing.Since the multi-angle compound technology can effectively improve the quality of imaging,this technology is applied to Doppler imaging to achieve high-accuracy velocity estimation.It can significantly reduce the velocity estimation errors.Comparing the velocity estimation accuracy of different angle compound numbers(n = 1,3,5,and 7) in the simulation,it is found that the accuracy of velocity estimation increases with angle compound increasing.Beside,the 5-angle compound method is more robust for velocity estimation and can obtain higher frames.The experiments were carried out using a programmable ultrasonic array system and a high-frequency linear array transducer L12-5c with a central frequency of 8.125 MHz.The sample rate is set to be 31.25 MHz.The imaging results of carotid bifurcation also show that the vector Doppler based on 5-angle compound can obtain a clear image of intravascular vector flow,which is beneficial to the identifying of complex flow state,and realize intravascular dynamic imaging.Especially,it can capture the vortex phenomenon in the blood stream.The quantitative results indi

关 键 词：多角度复合 超声多普勒 颈动脉分叉 矢量血流成像 

分 类 号：R445.1[医药卫生—影像医学与核医学] TP391.41[医药卫生—诊断学]