中兽药参黄颗粒的制备工艺优化研究  

Optimization of Preparation Technology of Chinese Veterinary Medicine Shenhuang Granules

作　　者：柯群华 吕亚楠 彭晶 吴雪琴 严作廷[1] 王胜义[1] KE Qun-hua;LV Ya-nan;PENG Jing;WU Xue-qin;YAN Zuo-ting;WANG Sheng-yi(Lanzhou Institute of Husbandry and PHarmaceutical Sciences/ Key Laboratory of Veterinary Medicine Innovation, Ministry of Agriculture and Rural Affairs, Lanzhou 730050,China)

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所/农业农村部兽用药物创制重点实验室,兰州730050

出　　处：《中国兽药杂志》2022年第5期53-62,共10页Chinese Journal of Veterinary Drug

基　　金：甘肃省重点研发计划项目(20YF8 NA028、20YF8 NA029);兰州市人才创新创业项目(2018-RC-91)。

摘　　要：为了优化中兽药参黄颗粒的制备工艺,获得最佳制备工艺参数,采用正交试验设计优化水提,浓缩,并采用湿法制粒,通过单因素试验和正交试验优选药物与辅料的比例、乙醇浓度和烘干温度参数,以颗粒的成型性、堆密度、休止角、溶化性以及吸湿性来评价颗粒的最佳成型工艺。最佳水提工艺为加9倍水,回流提取3次,每次提取时间1 h;药物与辅料比例为(3∶5)药物浸膏粉∶可溶性淀粉∶糊精∶蔗糖为(3∶2∶2∶1),乙醇浓度为80%,烘干温度为60℃,制备的颗粒剂综合评分最高。中兽药参黄颗粒的制备工艺优化研究为其临床试验的扩大生产提供了科学参考依据。In order to optimize the preparation parameters of traditional Chinese veterinary medicine Shenhuang granules,orthogonal design was adopted in the experiment for extraction,concentration and drying of traditional Chinese medicine by water extraction process,and wet granulate was adopted.The ratio of drug to excipatory,ethanol concentration and drying temperature were optimized by single factor test and orthogonal test.The best forming process of particles was evaluated by the formability,bulk density,repose Angle,solubility and hygroscopicity of particles.The results showed that the optimal extraction process was to add 9 times of water,reflux extraction for 3 times,each extraction time was 1 h.The ratio of drug to exchants was 3∶5(drug extract powder:soluble starch:dextrin:sucrose was 3∶2∶2∶1),ethanol concentration was 80%,drying temperature was 60℃,and the comprehensive score of prepared granules was the highest.The optimization of preparation technology of Chinese veterinary medicine Shenhuang granules provides a scientific reference for the expansion of clinical trial production.

关 键 词：参黄颗粒 正交实验 综合评分 工艺优化 

分 类 号：S859.79[农业科学—临床兽医学]