树突状细胞在缺氧微环境中的研究进展  

Progress of Dendritic Cell under Hypoxic Microenvironment

作　　者：张雷廷 余静 夏雨[1] 刘可 李遂焰[2] 严军 ZHANG Leiting;YU Jing;XIA Yu;LIU Ke;LI Suiyan;YAN Jun(State Key Laboratory of Trauma,Burns and Combined Injury,Key Laboratory of Extreme Environmental Medicine,Ministry of Education of China,Department of Special War Wound,Institute of Surgery Research,Daping Hospital,Army Medical University,Chongqing 400042,China;School of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China)

机构地区：[1]陆军军医大学大坪医院野战外科研究部特殊环境战伤防治研究室,极端环境医学教育部重点实验室,创伤、烧伤与复合伤国家重点实验室,重庆400042 [2]西南交通大学生命科学与工程学院,成都610031

出　　处：《中国细胞生物学学报》2022年第2期350-354,共5页Chinese Journal of Cell Biology

基　　金：教育部极端环境医学重点实验室开放课题(批准号:PR-KL2020GY004)资助的课题。

摘　　要：胚胎发育,高原生活,体育锻炼以及严重创伤、心血管疾病和肿瘤等都可能引起缺氧微环境,从而导致机体生理和病理特征的改变。缺氧微环境可通过免疫细胞直接影响机体免疫功能。树突状细胞(dendritic cell,DC)是体内最强的抗原递呈细胞(antigen presenting cell,APC),可有效连接天然免疫和适应性免疫,但其在不同微环境中的作用并不相同。因此,该文就DC在缺氧微环境中调控细胞分化、凋亡、迁移,抗原递呈和相关基因表达等生物学功能作一综述。Hypoxic microenvironment is resulted from many factors,such as embryogenesis,life on the plateau,physical exercise,severe trauma,cardiovascular disease and tumor,and leads to the characteristic changes of physiology and pathology.Moreover,hypoxic microenvironment may influence immunity function via immunocytes directly.DC (dendritic cell) is not only the strongest APC (antigen presenting cell) in vivo,but also a “bridge” between innate immunity and adaptive immunity.However,the roles of DC are not coincidental in different microenvironments.Thus,the biological functions of DC in differentiation,apoptosis,migration,antigen presenting and related gene expression under hypoxic microenvironment are reviewed in this paper.

关 键 词：树突状细胞 缺氧 微环境 

分 类 号：R392[医药卫生—免疫学]