岩黄连的化学成分及生物活性研究进展  

Research progress on chemical constituents and biological activities of Corydalis saxicola

作　　者：张晓 李保宏 张永康 梁红宝 姚景春 刘忠 秦国飞 张贵民 ZHANG Xiao;LI Bao-hong;ZHANG Yong-kang;LIANG Hong-bao;YAO Jing-chun;LIU Zhong;QIN Guo-fei;ZHANG Gui-min(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Shandong New Time Pharmaceutical Co.,Ltd.,Linyi 276006,China;State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine,Lunan Pharmaceutical Group Co.,Ltd.,Linyi 276006,China)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]山东新时代药业有限公司,山东临沂276006 [3]鲁南制药集团股份有限公司中药制药共性技术国家重点实验室,山东临沂276006

出　　处：《中草药》2022年第9期2861-2871,共11页Chinese Traditional and Herbal Drugs

基　　金：国家重大新药创制专项(2018ZX09201010-005);临沂市自主创新重大专项(2019ZDZX001)。

摘　　要：岩黄连Corydalis saxicola是我国西南地区的民间传统药物,临床上用于乙型肝炎、肝硬化、肝癌等肝病的治疗,极具开发价值。研究表明岩黄连中含丰富的生物碱、甾体、三萜、黄酮与核苷等类化合物,生物碱类为主要成分,多数化合物具有显著的生物活性,如抗病毒、抗炎、抗肿瘤、保肝、抑菌、抑制乙酰胆碱酯酶、镇痛等活性,特别是对乙肝、肝癌以及肝硬化等疾病的缓解作用比较显著。对岩黄连化学成分及生物活性的研究进展进行综述,以期为岩黄连的后续研究和深入开发提供参考。Corydalis saxicola,a traditional folk medicine in Southwest China,is used for treatment of hepatitis B,liver cirrhosis,liver cancer and other liver diseases in clinic,which has great development value.Studies have shown that there are abundant alkaloids,sterides,triterpenoids,flavonoids and nucleosides in C.saxicola,and alkaloids are the main components.Most of the compounds have significant biological activities,such as antiviral,anti-inflammatory,anti-tumor,hepatoprotective,antibacterial,inhibitory activity against acetylcholinesterase,and analgesic activities,etc.It has significant remission effects especially for hepatitis B,liver cancer,liver cirrhosis and other diseases.Research progress on chemical constituents and biological activities of C.saxicola were reviewed in this paper,in order to provide the reference for further research and development of C.saxicola.

关 键 词：岩黄连 生物碱 三萜 甾体 抗病毒 保肝 抑菌 镇痛 

分 类 号：R282.710.5[医药卫生—中药学]