夹脊盘龙刺对肝肾不足证帕金森病运动功能障碍的影响:随机对照试验  

Effect of panlong needling at Jiaji(EX-B 2) on motor dysfunction in patients with Parkinson’s disease of liver and kidney deficiency: a randomized controlled trial

作　　者：韩琳 苏秀贞 张中原[2] 刘颖 魏忠祥 张庆兰 张俊萍 王晨曦 苏全德 HAN lin;SU Xiu-zhen;ZHANG Zhong-yuan;LIU Ying;WEI Zhong-xiang;ZHANG Qing-lan;ZHANG Jun-ping;WANG Chen-xi;SU Quan-de(College of Acupuncture-Moxibustion and Tuina,Shandong University of TCM,Jinan 250355,China;Department of Acupuncture and Moxibustion,Weifang Hospital of TCM,Weifang 261041,Shandong Province)

机构地区：[1]山东中医药大学针灸推拿学院,济南250355 [2]潍坊市中医院针灸科,山东潍坊261041

出　　处：《中国针灸》2022年第5期493-497,共5页Chinese Acupuncture & Moxibustion

基　　金：潍坊市卫生健康委员会中医药科研项目:2020-4-018。

摘　　要：目的:比较夹脊盘龙刺联合西药与单纯西药治疗帕金森病(PD)运动功能障碍的疗效。方法:将98例PD患者随机分为针药组(49例,脱落1例)和西药组(49例,剔除1例)。西药组口服多巴丝肼片,首周每次125 mg,每日3次,第2周开始根据病情需要增加剂量,直至每次250 mg,每日3次,连续口服16周。针药组在西药组基础上取C2~L5夹脊穴行夹脊盘龙刺,每日1次,20次为一疗程,连续治疗4个疗程(16周)。分别于治疗前、治疗后及治疗结束后1个月随访评价两组患者帕金森病评定量表(UPDRS-Ⅲ、UPDRS-Ⅳ)评分、中医证候评分、帕金森患者生活质量问卷(PDQ-39)评分,并比较两组的安全性。结果:治疗后及随访时,除西药组PDQ-39评分外,两组UPDRS-Ⅲ、UPDRS-Ⅳ评分及中医证候评分、PDQ-39评分均较治疗前降低(P<0.05),且针药组均低于西药组(P<0.05)。针药组不良反应总发生率为10.4%(5/48),低于西药组的29.2%(14/48,P<0.05)。结论:夹脊盘龙刺联合西药治疗PD患者疗效优于单纯西药治疗,能明显改善患者运动功能障碍及临床症状,提高患者生活质量,且安全性较高。Objective To compare the curative effect of panlong needling at Jiaji(EX-B 2) combined with western medication and western medication alone on motor dysfunction in patients with Parkinson’s disease(PD) of liver and kidney deficiency. Methods A total of 98 patients with PD were randomly divided into an acupuncture and medication group(49 cases, 1 case dropped off) and a western medication group(49 cases,1 case was removed). The patients in the western medication group were given oral of levodopa and benserazide hydrochloride tablets, 125 mg each time, three times a day in the 1 st week, and the dose was increased according to the needs of the patients’ condition from the 2 nd week until 250 mg each time, three times a day, for 16 consecutive weeks. On the basis of the same western medication treatment as the western medication group, panlong needling was applied at Jiaji(EX-B 2) from C2 to L5 in the acupuncture and medication group,once a day, 20 times as a course of treatment, for 4 consecutive courses. The scores of unified Parkinson’s disease rating scale(UPDRS-Ⅲ, UPDRS-Ⅳ), TCM symptoms score, and 39-item Parkinson’s disease questionnaire(PDQ-39) score were evaluated before treatment, after treatment and during follow-up of 1 month after treatment, respectively. The safety of the two groups was compared. Results After treatment and during follow-up, except the PDQ-39 score of the western medication group, the scores of UPDRS-Ⅲ, UPDRS-Ⅳ, TCM syndrome and PDQ-39 were lower than those before treatment in the two groups(P<0.05), and the scores of above indexes in the acupuncture and medication group were lower than those of the western medication group(P<0.05). The total incidence of adverse reactions in the acupuncture and medication group was 10.4%(5/48), which was lower than 29.2%(14/48) in the western medication group(P<0.05). Conclusion Panlong needling at Jiaji(EX-B 2) combined with western medication could significantly improve the motor dysfunction and clinical symptoms, improve the quality

关 键 词：帕金森病 盘龙刺 穴 夹脊 运动功能障碍 随机对照试验(RCT) 

分 类 号：R246.6[医药卫生—针灸推拿学]