体育锻炼:介导骨骼肌昼夜节律分子钟的时间线索  

Physical Exercise:The Time Clue that Mediates the Molecular Clock of Skeletal Muscle Circadian Rhythm

作　　者：刘恒旭 陈佩杰[2] 卢文云 赵虹[4] 尹静 罗炯[1] LIU Hengxu;CHEN Peijie;LU Wenyun;ZHAO Hong;YIN Jing;LUO Jiong(Sports Detoxification Research Center,School of Physical Education,Southwest University,Chongqing 400715,China;School of Sports Science,Shanghai University of Sport,Shanghai 200438,China;School of Leisure,Shanghai University of Sport,Shanghai 200438,China;Department of Biochemistry and Molecular Biology,Shanxi Medical University,Taiyuan 030001,Shanxi,China;School of Basic Medical Sciences,Shanxi Medical University,Taiyuan 030001,Shanxi,China)

机构地区：[1]西南大学体育学院运动戒毒研究中心,重庆400715 [2]上海体育学院运动科学学院,上海200438 [3]上海体育学院休闲学院,上海200438 [4]山西医科大学生物化学与分子生物学教研室,山西太原030001 [5]山西医科大学基础医学院,山西太原030001

出　　处：《上海体育学院学报》2022年第6期94-106,共13页Journal of Shanghai University of Sport

基　　金：国家社会科学基金重大项目(19ZDA352)。

摘　　要：对体育锻炼介导骨骼肌分子钟的相关文献进行综述,分析骨骼肌分子钟与体育锻炼的关系。发现:体育锻炼可调节骨骼肌的分子钟,并影响昼夜节律的振幅和相位,骨骼肌的运动能力也受到昼夜节律基因振荡中断的影响,运动对骨骼肌时钟基因的表达亦具有特定的昼夜时间效应;体育锻炼介导骨骼肌昼夜节律分子钟的授时途径主要表现在中央时钟的间接介导、骨骼肌收缩直接驱动、细胞反应因子的诱导、应激激素释放的调节等方面;体育锻炼介导骨骼肌昼夜节律分子钟能有效改善骨骼肌萎缩、睡眠障碍、代谢性疾病和心血管疾病。认为:体育锻炼可在骨骼肌的昼夜节律系统中重新设置时钟,而个性化的定时锻炼亦可作为昼夜节律紊乱相关病理的有效处方,同时将运动和营养干预与分子钟同步也会最大限度地发挥体育锻炼对全身健康的促进作用。Related literature was reviewed to find how exercise induced the expression of skeletal muscle clock genes and the importance of exercise as synchronous stimulation of skeletal muscle circadian rhythm.It is found that physical exercise can mediate skeletal muscle circadian clock,and also influence its range and phase.The motion capability of skeletal muscle will also be affected by the vibration interruption of circadian clock.Clock gene has the function of myogenesis,transcription and metabolism.The potential time-serving pathways of physical exercise mediating skeletal muscle circadian clock are shown in the indirect mediation of central clock,the directly-driven skeletal muscle contraction,induction of cell factors,and the regulation of emergency hormone,etc.Physical exercise mediating skeletal muscle circadian clock can help improve the skeletal muscle atrophy,sleep barrier,metabolic and cardiovascular diseases.It is suggested that physical exercise can reset the clock in the skeletal muscle's circadian system.Furthermore,the individualized timing physical exercise can be used as an effective prescription of preventing disorders;in the meanwhile,the synchronization of physical exercise&nutrition intervention and molecular clock will put the improvement of overall health to the best use.

关 键 词：体育锻炼 骨骼肌 时钟基因 昼夜节律 转录翻译反馈环路 时间线索 

分 类 号：G804.2[文化科学—运动人体科学]