心血管跨尺度机制研究与生物力学模型  

Cardiovascular Cross-scale Mechanism Research and Biomechanical Model

作　　者：赵东良 任明明[2] 欧阳昆富 谭文长 Zhao Dongliang;Ren Mingming;Ouyang Kunfu;Tan Wenchang(School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School,Shenzhen 518055;Department of Cardiovascular Surgery,Peking University Shenzhen Hospital,Shenzhen 518036;College of Engineering,Peking University,Beijing 100871;Institute of Biomedical Engineering,Shenzhen Bay Laboratory,Shenzhen 518132;PKU-HKUST Shenzhen-Hong Kong Institution,Shenzhen 518057)

机构地区：[1]北京大学深圳研究生院化学生物学与生物技术学院,深圳518055 [2]北京大学深圳医院心血管外科,深圳518036 [3]北京大学工学院,北京100871 [4]深圳湾实验室生物医学工程研究所,深圳518132 [5]深港产学研基地,深圳518057

出　　处：《中国科学基金》2022年第2期235-244,共10页Bulletin of National Natural Science Foundation of China

基　　金：国家自然科学基金项目(81970421,82170235,11732001);国家重点研发计划重点项目(2021YFA1000200);广东省引进领军人才计划项目(1120133463);深圳市海外高层次人才团队研究项目(KQTD20180411143400981);深圳市科技计划(JCYJ20210324130401005);深圳湾实验室科研启动项目(21300021)资助。

摘　　要：心血管系统在时间和空间上均具有多尺度特点,其中微观机制决定着微观结构并最终影响宏观功能。目前,心血管系统研究在各个尺度上均有一定进展,但各维度的整合与应用还处于起步阶段。结合分子生物学与细胞生物学技术、多组学技术、小动物模型构建技术、多尺度成像与功能检测技术以及计算机建模技术,将不同尺度实验数据进行整合,可以更好地理解心血管生理与病理特征。这种研究模式已在心肌钙信号、心脏与血管重塑、血流动力学、心脏动力学等研究中得到应用,为相关机制研究提供了新思路和新途径,并有望在分子到生理水平上实现对心血管系统的虚拟仿真,从而为特异性心血管疾病诊断、手术方案设计、非侵入性精准诊断、预测评估等提供新方法和新标准。The cardiovascular system has multi-scale characteristics in time and space,in which the micro mechanism determines the micro structure and ultimately affects the macro function.At present,research on the cardiovascular system has made certain progress of various scales,but the integration and application of various dimensions is still in its infancy.Combining molecular biology and cell biology technology,multi-omics technology,small animal model construction technology,multi-scale imaging and functional testing technology,and computer modeling technology,integrating experimental data at different scales can better understand cardiovascular physiology and pathological features.This research model has been applied in the research of cardiac calcium signals,heart and blood vessel remodeling,hemodynamics,myocardial mechanics.It provides new ideas and new ways for the research of related mechanisms,and is expected to be at the molecular to physiological level.The virtual simulation of the cardiovascular system,so as to provide new methods and new standards for specific cardiovascular disease diagnosis,surgical plan design,non-invasive precision diagnosis,predictive evaluation.

关 键 词：心血管生物力学 血流动力学 心肌力学 多尺度建模 

分 类 号：R54[医药卫生—心血管疾病]