内耳毛细胞再生相关的信号通路及信号互作研究进展  

Research Progress of Signaling Pathways and their Interactions in Inner Ear Hair Cell Regeneration

作　　者：杨影 陈凤娇 陆婷婷 陆莹 丁洁 YANG Ying;CHEN Fengjiao;LU Tingting;LU Yin;DING Jie(Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education),Collaborative Innovation Center for Mountain Ecology&Agro-Bioengineering(CICMEAB),College of Life Sciences/Institute of Agro-bioengineering,Guizhou University,Guiyang 550025,China;Sanzao Town Central Primary School,Jinwan District,Zhuhai 519040,China;Department of Deplaning,Basic Medical College,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China)

机构地区：[1]贵州大学生命科学学院/农业生物工程研究院,山地植物资源保护与保护种质创新教育部重点实验室,山地生态与农业生物工程协同创新中心,贵阳550025 [2]珠海市金湾区三灶镇中心小学,珠海519040 [3]贵州中医药大学基础医学院解刨学教研室,贵阳550025

出　　处：《中国细胞生物学学报》2022年第3期460-468,共9页Chinese Journal of Cell Biology

基　　金：贵州省科技厅(批准号:ZK[2021]108);贵州省教育厅(批准号:KY[2017]113);国家自然科学基金(批准号:81960838)资助的课题。

摘　　要：内耳毛细胞是一种感受器,负责将机械声能转化为神经脉冲,使机体感知外界声音。毛细胞的功能丧失是永久性感音性神经耳聋的主要原因之一,毛细胞在成体哺乳动物中不会自发再生,研究人员通过模拟哺乳动物内耳损伤,发现Notch信号通路通过侧抑制和侧诱导作用形成新的感觉毛细胞。Notch的下游信号Wnt和上游信号FGF-FGFR是促进内耳发育、细胞增殖、分化以及毛细胞再生的关键信号通路。因此,了解Notch、Wnt、FGF等信号通路及相关转录因子在哺乳动物内耳毛细胞再生过程中的作用机制极为重要,该文重点阐述Notch信号通路以及相关信号分子互作在内耳毛细胞再生中的调控作用,旨在分析耳蜗毛细胞增殖和再生的调控机制,为耳聋治疗方法的实验研究和临床应用提供理论参考。Hair cells are sensory receptors located in the inner ear,which are responsible for converting mechanical sound energy into nerve impulses,allowing the body to perceive external sounds.In mature mammals,when hair cells in the inner ear are destroyed,they cannot regenerate and cause permanent sensor neural hearing loss.Researchers simulated the injury of the inner ear in mammals and found that the Notch signaling pathway forms new sensory hair cells through lateral inhibition and lateral induction.Notch’s downstream signal Wnt and upstream signal FGF-FGFR are the key signal pathways that promote inner ear development,cell proliferation,differentiation and hair cell regeneration.Therefore,it is extremely important to understand the mechanism of Notch,Wnt,FGF and other signaling pathways and related transcription factors in the process of mammalian inner ear hair cell regeneration.This article focuses on the regulation of the Notch signaling pathway and the interaction of related signal molecules in the regeneration of inner ear hair cells,aiming to analyze the regulation mechanism of cochlear hair cell proliferation and regeneration,and provide theoretical reference for experimental research and clinical application of deafness treatment.

关 键 词：内耳毛细胞再生 NOTCH WNT FGF 信号互作 

分 类 号：R764[医药卫生—耳鼻咽喉科]