自噬对再生中肌肉干细胞的作用  

The Role of Autophagy on Muscle Stem Cells during Regeneration

作　　者：陈炜 陈雨诗[1,2,3,4] 刘禹熙 王新霞 CHEN Wei;CHEN Yushi;LIU Yuxi;WANG Xinxia(College of Animal Sciences,Zhejiang University,Hangzhou 310058,China;Key Laboratory of Molecular Animal Nutrition(Zhejiang University),Ministry of Education,Hangzhou 310058,China;Key Laboratory of Animal Nutrition and Feed Science(Eastern of China),Ministry of Agriculture and Rural Affairs,Hangzhou 310058,China;Key Laboratory of Animal Feed and Nutrition of Zhejiang Province,Hangzhou 310058,China)

机构地区：[1]浙江大学动物科学学院,杭州310058 [2]浙江大学教育部“动物分子营养学”重点实验室,杭州310058 [3]农业农村部(华东)动物营养与饲料重点实验室,杭州310058 [4]浙江省饲料与动物营养重点实验室,杭州310058

出　　处：《中国细胞生物学学报》2022年第3期484-491,共8页Chinese Journal of Cell Biology

基　　金：国家重点研发计划(批准号:2018YFD0500405)资助的课题。

摘　　要：各种遗传缺陷、实质性组织损伤或外源性信号的改变均可引起骨骼肌肌肉组织的损伤,并导致各种原发性或继发性肌病。因此,了解肌肉再生中的生理过程和相关分子机制将有助于更有效的组合治疗策略。自噬最初被认为是营养物质分解的机制,随后的研究进一步发现自噬也是一种降解细胞质成分、蛋白质聚集体和细胞器的生理过程,是细胞结构的调节器,广泛参与细胞应激和分化过程。对自噬抑制的研究表明了自噬对成功的肌肉再生是必不可少的,其中一个关键机制是影响肌肉干细胞(muscle stem cells,MuSCs)的分化命运。因此,了解自噬在其中的作用将有助于更有效的临床治疗。在此,该文回顾了近年来有关自噬对肌肉再生中的MuSCs作用的文献,为通过调节自噬治疗再生缺陷性肌病提供相关参考。Various hereditary defects,substantial tissue damage,or alterations in extrinsic signalling could impair the regeneration of muscle tissue and lead to various primary or secondary myopathies.Therefore,understanding the physiological processes and related molecular mechanisms in muscle regeneration will contribute to more effective combined treatment strategies.Autophagy was initially considered as the mechanism of nutrient decomposition.Subsequent studies further find that autophagy is also a physiological process of degrading cytoplasmic components,protein aggregates and organelles,which is a regulator of cell structure and widely participates in the process of cell stress and differentiation.The studies of autophagy inhibition show that autophagy is essential for successful muscle regeneration,and one of the key mechanisms is to affect the differentiation fate of MuSCs (muscle stem cells).Therefore,understanding the role of autophagy will contribute to more effective clinical treatment.Here,this article reviews the literature on the role of MuSCs in muscle regeneration by autophagy in recent years,so as to provide relevant references for the treatment of regeneration deficient myopathy by regulating autophagy.

关 键 词：自噬 肌肉干细胞 再生 分化 

分 类 号：R685[医药卫生—骨科学]