郑州地区SLCO1B1和ApoE基因多态性分布情况  

Polymorphism analysis of SLCO1B1 and ApoE genes in Zhengzhou area

作　　者：韩勇军 张亚威[1] 高伟 毛海珍 高水波 吴鸿 HAN Yong-jun;ZHANG Ya-wei;GAO Wei;MAO Hai-zhen;GAO Shui-bo;WU Hong(Central Lab,Henan Provincial Hospital of TCM,Zhengzhou 450002,Henan,China;Second Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China;Department of Environment and Life Sciences,Beijing University of Technology,Beijing 100124,China)

机构地区：[1]河南省中医院(河南中医药大学第二附属医院)中心实验室,河南郑州450002 [2]河南中医药大学第二临床医学院,河南郑州450046 [3]北京工业大学环境与生命学部,北京100124

出　　处：《心脏杂志》2022年第1期44-48,共5页Chinese Heart Journal

基　　金：河南中医学院科研苗圃工程项目资助(MP2016-10);2019年国家中医临床研究基地科研专项资助(2019JDZX023)。

摘　　要：目的调研SLCO1B1与载脂蛋白E(ApoE)基因多态性在郑州地区的分布情况,评估其对服用他汀类药物的风险。方法入选2018年7月~2019年7月间在河南省中医院1037例心脑血管疾病住院患者,应用荧光探针-PCR技术检测全血中SLCO1B1与ApoE基因型。统计分析其基因型在受检者的年龄和性别中的分布特点,对比分析其他地区的相关数据。结果发现受检患者中SLCO1B1 I类基因型(^(*)1a/^(*)1a+^(*)1a/^(*)1b+^(*)1b/^(*)1b)、II类基因型(1a/^(*)5+^(*)1a/^(*)15+^(*)1b/^(*)15)和III类基因型(^(*)5/^(*)5+^(*)5/^(*)15+^(*)15/^(*)15)分别占75.6%、22.7%和1.6%;ApoE E2基因型(E2/E2+E2/E3)、E3基因型(E2/E4+E3/E3)和E4基因型(E3/E4+E4/E4)分别占13.6%、70.5%和15.9%。分析发现SLCO1B1和ApoE基因型组合在年龄和性别间分布差异均无统计学意义,与武汉、长沙、广州地区心脑血管疾病患者相比,郑州地区SLCO1B1和ApoE基因型组合分布差异无统计学意义。结论郑州地区心脑血管疾病患者SLCO1B1和ApoE基因多态性分别以I类基因型和E3基因型为主,且两种基因型各组合均不受年龄及性别的影响,基因型组合分布无地域特征。AIM To understand the polymorphism distribution of SLCO1B1 and ApoE genes in Zhengzhou area and to explore the risk assessment of the use of statins.METHODS The SLCO1B1 and ApoE genotypes in the whole blood of 1037 patients with cardiovascular and cerebrovascular diseases in the inpatient department of Henan provincincal hospital of TCM from July 2018 to July 2019 were qualitatively detected by PCR-fluorescence probe technology.The distribution characteristics of SLCO1B1 and ApoE genotypes were analyzed according to the age and the gender of the subjects,and the data of other regions were compared.RESULTS The results showed that the I genotype(^(*)1a/^(*)1a+^(*)1a/^(*)1b+^(*)1b/^(*)1b),II genotype(1a/^(*)5+^(*)1a/^(*)15+^(*)1b/^(*)15)and III genotype of SLCO1B1 in the tested population accounted for 75.6%,22.7% and 1.6%,respectively.ApoE E2 genotype(E2/E2+E2/E3),E3 genotype(E2/E4+E3/E3)and E4 genotype(E3/E4+E4/E4)accounted for 13.6%,70.5% and 15.9%,respectively.SLCO1B1 and ApoE genotype groups showed no significant difference in distribution between age groups and genders.Compared with patients with cardiovascular and cerebrovascular disease in Wuhan,Changsha and Guangzhou,the combination and distribution of the 2 genotypes in Zhengzhou showed no significant difference.CONCLUSION The polymorphisms of SLCO1B1 and ApoE genes of patients with cardiovascular and cerebrovascular diseases in Zhengzhou are mainly I genotype and E3 genotype,and the combinations of the 2 genotypes are not affected by age,gender and region.

关 键 词：SLCO1B1 APOE 基因型多态性 他汀 心脑血管疾病 

分 类 号：R54[医药卫生—心血管疾病]