心室重构及其与能量代谢重构发生发展的关系  

Ventricular remodeling and its relationship with energy metabolism remodeling

作　　者：王茹 王承龙[1] WANG Ru;WANG Cheng-long(National Clinical Research Center for Chinese Medicine Cardiology,Xiyuan Hospital,China Academy of Chinese Medical Science,Beijing 100091,China)

机构地区：[1]中国中医科学院西苑医院国家中医心血管病临床医学研究中心,北京100091

出　　处：《心脏杂志》2022年第1期89-93,共5页Chinese Heart Journal

基　　金：国家自然科学基金项目资助(81874410)。

摘　　要：慢性心力衰竭是各种心脏疾病的终末阶段,其标志就是心脏损伤后的不良心室重构。目前,对心室重构的病理生理学机制的理解主要集中于神经内分泌系统的激活上,然而,越来越多的证据表明,这不能完全解释心室重构病理生理的复杂性。心肌代谢重构概念提出之后,代谢重构与心室重构、心力衰竭的关系日益成为研究重点,以心肌代谢重构为靶点的心肌代谢疗法在防治心室重构中的作用也日益突出。Chronic heart failure is the end stage of various heart diseases and its hallmark is ventricular remodeling after heart injury.The neuroendocrine activation paradigm is the cornerstone of current pathophysiological understanding of ventricular remodeling,however,there is increasing evidence that this cannot fully explain the complexity of ventricular remodeling.After the concept of myocardial metabolic remodeling was proposed,the relationship between metabolic remodeling,ventricular remodeling and heart failure has increasingly become the focus of research.Myocardial metabolic therapy targeting myocardial metabolic remodeling has become increasingly prominent in the prevention and treatment of ventricular remodeling.

关 键 词：心肌能量代谢 心室重构 代谢重构 心力衰竭 心肌代谢疗法 

分 类 号：R541.6[医药卫生—心血管疾病]