电针刺激内关穴对模拟失重大鼠心脑血管氧化应激的影响  

Effect of electroacupuncture at Neiguan Acupoint on simulated weightlessness induced cardiovascular oxidative stress

作　　者：高原 孙静 李小涛[3] 杨长斌 王永春 孙喜庆 GAO Yuan;SUN Jing;LI Xiao-tao;YANG Chang-bing;WANG Yong-chun;SUN Xi-qing(Department of Aerospace Medicine,Air Force Medical University,Xi’an 710032,Shaanxi,China;Department of Anesthesiology,Northwest Women and Children’s Hospital,Xi’an 710061,Shaanxi,China;Institute of Environmental Physiology and Conditioning,Xidian University,Xi’an 710126,Shaanxi,China)

机构地区：[1]空军军医大学航空航天医学系,陕西西安710032 [2]西北妇女儿童医院麻醉科,陕西西安710061 [3]西安电子科技大学特殊环境生理与体能训练军民融合创新研究中心,陕西西安710126

出　　处：《心脏杂志》2022年第2期210-214,共5页Chinese Heart Journal

基　　金：空间站工程航天医学实验项目资助(HYZHXM05007);国家自然科学基金项目资助(81301682)。

摘　　要：目的探讨电针刺激内关穴对模拟失重大鼠心脑血管氧化应激水平的影响。方法30只雄性SD大鼠随机分为尾吊组、穴位刺激尾悬吊组和对照组,尾吊组和穴位刺激尾吊组大鼠均头低位-30°尾吊7 d,穴位刺激尾吊组大鼠需进行每天30 min的电针刺激内关穴,对照组不做任何处理。三组均在7 d后测量血清、心脏组织、脑组织、颈动脉及股动脉的超氧化物歧化酶(SOD)和丙二醛(MDA)含量。结果尾悬吊后大鼠血清及各血管组织中SOD含量显著低于对照组,MDA含量则显著高于对照组(P<0.05)。给予电针刺激后,穴位刺激尾悬吊组大鼠SOD和MDA含量与对照组相比无显著差异。结论电针刺激大鼠内关穴可减轻7 d尾悬吊模拟失重效应所产生的心脑血管氧化应激。AIM To investigate the effect of electroacupuncture(EA)at Neiguan Acupoint on simulated weightlessness induced cardiovascular oxidative stress.METHODS Thirty male SD rats were randomly divided into three groups:tail-suspension(SUS)group,SUS+EA group and control group.All the rats in the SUS group and SUS+EA group had their heads lowered to-30°for 7 days.The rats in the tail-suspension with electroacupuncture stimulation group also had to undergo electroacupuncture stimulation of Neiguanacupoint for 30 min every day,while the control group did not do any treatment.The contents of superoxide dismutase(SOD)and malondialdehyde(MDA)in serum,heart tissue,brain tissue,carotid artery and femoral artery were measured after 7 days in all the three groups.RESULTS After tail-suspension,SOD content in serum and vascular tissue was significantly lower than that in control group,while MDA content was significantly higher than that in control group(P<0.05).After electroacupuncture stimulation,the content of SOD and MDA in serum in SUS+EA group had no significant difference compared with those in control group.CONCLUSION Electroacupuncture stimulation at Neiguan Acupoint in rats reduces cardiovascular and cerebrovascular oxidative stress induced by simulated weightlessness of tail suspension for 7 days.

关 键 词：模拟失重 电针 内关穴 心脑血管 氧化应激 

分 类 号：R85[医药卫生—航空、航天与航海医学]