中药有效成分防治骨肉瘤转移作用与机制研究进展  

Research Progress on the Effect and Mechanism of Effective Components of Traditional Chinese Medicine in Preventing and Treating Osteosarcoma Metastasis

作　　者：赵福来 常君丽[1,2] 支文兰 王晓波 孙星媛 马小平 施杞[1,2] 王拥军[1,2] 杨燕萍[1,2] Zhao Fulai;Chang Junli;Zhi Wenlan;Wang Xiaobo;Sun Xingyuan;Ma Xiaoping;Shi Qi;Wang Yongjun;Yang Yanping(Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Key Laboratory of Musculoskeletal Theory and Treatment Principle,Ministry of Education,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]教育部筋骨理论与治法重点实验室,上海200032

出　　处：《世界科学技术-中医药现代化》2022年第2期482-489,共8页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家科学技术部国家重点研发计划-中医药现代化研究重点专项(2018YFC1704300):“肾阳虚证”辨识方法和临床指导原则的应用研究,负责人:王拥军;国家科学技术部战略性国际科技创新合作重点专项(2020YFE0201600):人类表型组测量技术及表型数据跨尺度关联合作研究,负责人:杨燕萍;国家自然科学基金委员会面上项目(81973877):LncRNA-CCDC18-AS1激活YAP/TAZ诱导骨肉瘤发生及加味芪重散作用的机制研究,负责人:杨燕萍。

摘　　要：骨肉瘤是一种原发性、侵袭性恶性肿瘤,极易发生早期转移且缺乏有效治疗靶点。手术和放化疗及二者的联合应用是目前主要的治疗手段,但对转移性骨肉瘤患者总体生存率的提高仍未有明显改善。骨肉瘤在中医属于“癌病”范畴,中医药治疗骨肉瘤历史悠久,并且在防治骨肉瘤转移方面能够发挥积极作用,但其机制尚未十分明确。信号通路在骨肉瘤转移的发生过程中具有重要作用,并且是研究骨肉瘤转移的病理机制和治疗药物的作用靶点之一。近年来,针对中药有效成分防治骨肉瘤转移相关信号通路进行了大量研究,现将此做一综述,以期为中医药防治骨肉瘤转移、新药开发和临床诊治提供借鉴。Osteosarcoma is a primary and aggressive malignant tumor, which is prone to early metastasis and lacks effective therapeutic targets. Surgery, chemoradiotherapy and the combination of the two are the main treatment methods at present, but the overall survival rate of patients with metastatic osteosarcoma has not been significantly improved.Osteosarcoma belongs to the category of "cancer disease" in traditional Chinese medicine. Traditional Chinese medicine has a long history in the treatment of osteosarcoma and can play an active role in the prevention and treatment of osteosarcoma metastasis, but its mechanism is not clear yet. Signaling pathway plays an important role in the pathogenesis of osteosarcoma metastasis and is one of the targets for the study of pathologic mechanism of osteosarcoma metastasis and therapeutic drugs. In recent years, large number of studies have been conducted on the signaling pathways related to the prevention and treatment of osteosarcoma metastasis by effective components of traditional Chinese medicine. This review is expected to provide reference for the prevention and treatment of osteosarcoma metastasis by traditional Chinese medicine, new drug development and clinical diagnosis and treatment.

关 键 词：中药有效成分 骨肉瘤 转移 作用机制 研究进展 

分 类 号：R285[医药卫生—中药学]