甘肃地区中医药治疗肝癌的研究热点及用药规律分析  

Analysis of Research Hotspots and Medication Rules of Traditional Chinese Medicine for Liver Cancer in Gansu

作　　者：秦三利[1,2] 齐江华 张仲男[1] 石昕[1] 林静[1] 焦丽莎[1] 丁颖 张渊厚 宋文[1] 单金姝[2] Qin Sanli;Qi Jianghua;Zhang Zhongnan;Shi Xin;Lin Jing;Jiao Lisha;Ding Ying;Zhang Yuanhou;Song Wen;Shan Jinshu(Institute of Gansu Medical Science Research,Lanzhou 730050,China;Gansu Cancer Hospital,Lanzhou 730050,China)

机构地区：[1]甘肃省医学科学研究院,兰州730050 [2]甘肃省肿瘤医院,兰州730050

出　　处：《世界科学技术-中医药现代化》2022年第2期513-520,共8页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：甘肃省中医药管理局中医文献研究(GZK-2017-45):基于文献和社会网络分析的中医药治疗肝癌现状与趋势研究,负责人:张仲男。

摘　　要：目的分析甘肃地区中医药治疗肝癌的研究热点及用药规律,为进一步优化肝癌治疗方法提供思路和依据。方法检索2006年1月至2021年6月中国生物医学文献服务系统、中国知网、万方数据知识服务平台、MEDLINE等数据库收录的关于甘肃地区中医药治疗肝癌的文献,运用Excel及SPSS统计软件对文献类型、年度分布、临床治疗情况以及中药应用情况进行统计分析,同时对高频关键词进行聚类分析。结果筛选出有效文献183篇,其中实验研究132篇(72.13%),临床研究文献33篇(18.03%),名家经验7篇(3.83%),综述9篇(4.92%),循证研究2篇(1.09%);除2007年及2008年个别年度外,其余年度的发文量相对稳定,均在10篇以上;对临床研究及实验研究文献中高频关键词进行聚类分析均得到4组聚类组合;名家经验研究均为裴正学教授治疗原发性肝癌的经验报道;涉及中药煎服、中药静滴、中药口服、中药外敷及中药灌注5种中医药治疗方法;主要临床观察指标为生活质量、临床近期疗效、肝功能、临床症状、毒副反应、甲胎蛋白(alpha fetoprotein,AFP)、瘤体大小及生存期;涉及29首中药处方,其中内服中药方12首,外敷中药方1首,其它自拟方16首;内服方中涉及99味中药,应用频次较高的为半枝莲、白术、柴胡、黄芪、茯苓及丹参,按单味中药进行归类,补虚药应用最多,占21.09%,其次为活血化瘀药和清热药,分别占16.73%和10.91%;涉及21味外敷中药,应用频次较高的为莪术、没药及乳香。结论甘肃地区中医药治疗肝癌方面文献以实验研究为主;中药应用以补虚药为主,体现出原发性肝癌中医辨证以虚为主,虚实夹杂的特点,治疗上既重视益气健脾,又施以清热解毒、活血化瘀、疏肝理气及利水渗湿等治法。此外,中医药联合经导管动脉化疗栓塞术(transcatheter arterial chemoembolization,TACE)对晚期原发性肝癌患者的疗效和不同中药提�Objective To provide ideas and basis for further optimization of the treatment of liver cancer by analyzing the research hotspots and medication rules of traditional Chinese medicine in the treatment of liver cancer in Gansu.Methods The literature on the treatment of liver cancer in Gansu was searched by the Chinese Biomedical Literature Service System, CNKI, Wanfang Data Knowledge Service Platform, MEDLINE and other databases from January 2006 to June 2021, and Excel and SPSS statistical software were used to analyze the literature types, annual distribution, clinical treatment and application of traditional Chinese medicine and cluster analysis of high-frequency keywords. Results 183 effective literatures were screened out, including 132 experimental studies(72.13%), 33 clinical research literatures(18.03%), 7 expert experiences(3.83%), 9 reviews(4.92%), and 2 evidence-based studies(1.09%). Except for 2007 and 2008, the number of publications in other years was relatively stable, with more than 10 articles per year. The cluster analysis of high-frequency keywords in clinical research and experimental research literature resulted in 4 clusters combination. Famous experts’ experience research was Professor Pei Zhengxue’s experience report on the treatment of primary liver cancer. Chinese medicine decoction, Chinese medicine intravenous drip, Chinese medicine oral administration, Chinese medicine external application and Chinese medicine perfusion were involved. The frequency of main clinical observation indicators was quality of life, clinical short-term efficacy, liver function, clinical symptoms,toxic and side effects, alpha fetoprotein, tumor size, and survival;29 traditional Chinese medicine prescriptions were involved, including 12 traditional Chinese medicine prescriptions for oral administration and 1 traditional Chinese medicine prescription for external use and 16 other self-made prescriptions. 99 traditional Chinese medicines were involved in the oral prescriptions, and the most frequently used ones

关 键 词：中医药 肝癌 聚类分析 研究热点 用药规律 甘肃 

分 类 号：R392.11[医药卫生—免疫学]