神门、三阴交配伍对失眠症睡眠质量和血清GABA、5-HT的影响  

Effects of Shenmen(HT7) and Sanyinjiao(SP6) Acupoint Compatibility on Sleep Quality, Serum GABA and 5-HT in Insomnia

作　　者：李仲文 杨玲[2] 宋孝军 杜莉 诸毅晖[1] Li Zhongwen;Yang Ling;Song Xiaojun;Du Li;Zhu Yihui(School of Acupuncture,Moxibustion and Tuina,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;The Affiliated Hospital of Chengdu University of TCM,Chengdu 610075,China)

机构地区：[1]成都中医药大学针灸推拿学院,成都610075 [2]成都中医药大学附属医院,成都610075

出　　处：《世界科学技术-中医药现代化》2022年第2期860-866,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会面上项目(81673885):神门、三阴交的穴位配伍效应及其安神机制研究,负责人:诸毅晖。

摘　　要：目的探索神门-三阴交改善失眠症睡眠质量的穴位配伍效应及神经递质调控机制。方法将90例失眠症患者以每组30例随机分至神门组、三阴交组、神门-三阴交组。共54例受试者完成PSG监测,其中神门组16例,三阴交组13例,神门-三阴交组15例,与健康组10例进行对照。三组患者分别电针神门、三阴交、神门-三阴交30 min,疏密波,频率5Hz/25Hz,每天治疗1次,5次为1个疗程,共2个疗程,疗程间间隔2天。采用SDRS量表、PSG监测评价失眠症患者睡眠质量,检测血清GABA、5-HT含量揭示神门-三阴交穴位配伍的神经递质调控机制。结果(1)治疗后,三组失眠症患者SDRS评分较治疗前降低(P<0.05),神门-三阴交组、三阴交组SDRS评分明显低于神门组(P<0.05)。(2)完成PSG失眠症患者治疗后与治疗前比较,神门组总睡眠时间延长、睡眠潜伏期缩短、睡眠效率提高,血清GABA含量升高(P<0.05);三阴交组总睡眠时间延长、睡眠潜伏期缩短、睡眠效率提高,血清5-HT含量升高(P<0.05);神门-三阴交组总睡眠时间延长、睡眠潜伏期和入睡后清醒时间缩短、睡眠效率提高,血清GABA、5-HT含量均明显升高(P<0.05)。治疗后,神门-三阴交组较神门组总睡眠时间延长、睡眠潜伏期缩短、睡眠效率提高(P<0.05),血清GABA、5-HT含量明显升高(P<0.05)。结论神门-三阴交在改善失眠症状、提高睡眠质量方面具有穴位配伍效应优势,三阴交穴发挥主导作用。神门-三阴交可能通过上调血清GABA、5-HT含量发挥穴位配伍效应。Objective To explore the acupoint compatibility effect and neurotransmitter regulation mechanism of Shenmen(HT7)-Sanyinjiao(SP6) for improving sleep quality of insomnia.Methods Ninety patients were divided into Shenmen(HT7) group, Sanyinjiao(SP6) group, and Shenmen(HT7)-Sanyinjiao(SP6) group, with 30 cases in each group. 54 subjects completed PSG monitoring, including 16 cases in the Shenmen(HT7) group, 13 cases in the Sanyinjiao(SP6) group, 15 cases in the Shenmen(HT7)-Sanyinjiao(SP6) group, and 10 cases in the healthy group for comparison. The three groups of patients were electroacupuncture Shenmen(HT7), Sanyinjiao(SP6), Shenmen(HT7)-Sanyinjiao(SP6). The daily electroacupuncture time was 30 minutes, with wave of condensation and rarefaction and the frequency of 5Hz or 25Hz, and the 5 days was a course of treatment, a total of 2 courses, and a rest between treatments for 2 days. The SDRS scale and PSG monitoring were used to evaluate the sleep quality of patients with insomnia, and the serum GABA and 5-HT contents were detected to reveal the neurotransmitter regulation mechanism of Shenmen(HT7)-Sanyinjiao(SP6) acupoint compatibility.Results(1) After treatment, the SDRS scores of the three groups of insomnia patients were decreased than before treatment(P<0.05), and the SDRS scores of the Shenmen(HT7)-Sanyinjiao(SP6) group and Sanyinjiao(SP6) group were significantly lower than the Shenmen(HT7) group(P<0.05).(2)When the insomnia patients who completed PSG monitoring after treatment were compared with those before treatment,total sleep time was prolonged, and sleep latency was shortened. Sleep efficiency was improved, and serum GABA content was increased(P<0.05). After treatment in the Sanyinjiao(SP6) group, total sleep time was prolonged, and sleep latency was shortened. Sleep efficiency was improved, and serum 5-HT content was increased(P<0.05). After treatment in the Shenmen(HT7)-Sanyinjiao(SP6) group, total sleep time was prolonged, and sleep latency and wake-up time after falling asleep were shortened. Sleep

关 键 词：失眠症 神门 三阴交 穴位配伍 

分 类 号：R245.9[医药卫生—针灸推拿学]