丹参酮注射液对非ST段抬高型心肌梗死PCI后支架内再狭窄的影响  

Effect of Tanshinone Injection on In-Stent Restenosis after PCI of Non-ST Segment Elevation Myocardial Infarction

作　　者：赵躬英 黄刚[1] 林霞 Zhao Gongying;Huang Gang;Lin Xia(Department of Cardiology,Suining Central Hospital,Suining 629000,China;不详)

机构地区：[1]遂宁市中心医院心血管内科,遂宁629000

出　　处：《中国循证心血管医学杂志》2022年第4期423-426,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：四川省教育厅科研基金重点项目(15ZA0209)。

摘　　要：目的 探讨丹参酮ⅡA磺酸钠注射液对非ST段抬高型心肌梗死(NSTEMI)经皮冠状动脉介入治疗(PCI)后支架内再狭窄的影响。方法 选取2018年1月至2020年12月于遂宁市中心医院心血管内科行PCI的NSTEMI患者72例为研究对象。根据治疗方式不同分为观察组(37例)与对照组(35例),对照组患者术后给予常规西药治疗,观察组术后在对照组基础上加用丹参酮ⅡA磺酸钠注射液治疗。观察两组患者血清学指标:超敏C反应蛋白(hs-CRP)、超氧化物歧化酶(SOD)、一氧化氮(NO)及纤溶酶原激活物抑制物-1(PAI-1),支架内最小管腔内径(MLD)、支架内再狭窄发生率及不良心血管事件(MACE)。结果 治疗后,观察组术后hs-CRP、SOD、NO及PAI-1均明显优于对照组(P<0.05)。术后3个月,两组患者MLD均减小,且观察组大于对照组(P<0.05);两组患者支架内再狭窄发生率比较无统计学差异(P>0.05)。两组患者MACE发生率比较无统计学差异(P>0.05)。结论 丹参酮ⅡA磺酸钠注射液能有效改善患者氧化应激及炎症反应,具有调节纤溶系统平衡及保护血管内皮的功能,并可延缓NSTEMI患者PCI后再狭窄进程,安全性较好。Objective To investigate the effect of Tanshinone ⅡA sodium sulfate injection on in-stent restenosis after percutaneous coronary intervention(PCI) for non-ST-segment elevation myocardial infarction(NSTEMI).Methods A total of 72 NSTEMI patients undergoing PCI who were admitted to the hospital from January 2018 to December 2020 were selected.Different treatment methods were divided into observation groups(37 cases) and control groups(35 patients).The control group was treated with conventional western medicine after the operation.The observation group was treated with Tanshinone ⅡA sodium sulfate injection based on the control group after the operation.The serum indexes {hypersensitive C-reactive protein(hs-CRP),superoxide dismutase(SOD),nitric oxide(NO) and plasminogen activator inhibitor-1(PAI-1)},the in-stent minimum lumen diameter(MLD),the incidence of restenosis in the stent,and adverse cardiovascular events(MACE) were observed.Results After treatment,hs-CRP,SOD,NO,and PAI-1 in the observation group were significantly better than those in the control group(P<0.05).Three months after surgery,the MLD of the two groups of patients decreased,and the observation group was larger than the control group(P<0.05).The incidence of in-stent stenosis in the two groups was not significant(P>0.05).The incidence of MACE between the two groups was insignificant(P>0.05).Conclusion Tanshinone ⅡA sodium sulfate injection can effectively improve patients’ oxidative stress and inflammation,adjust the balance of the fibrinolytic system and protect the vascular endothelium,which can also delay the restenosis of NSTEMI patients undergoing PCI with good safety.

关 键 词：非ST段抬高型心肌梗死 丹参酮注射液 PCI 支架内再狭窄 

分 类 号：R542.22[医药卫生—心血管疾病]