乙醛脱氢酶2基因G487A位点多态性与冠心病患者冠状动脉病变程度的关系  

Relationship between of ALDH2 gene G487A polymorphism and severity of coronary artery lesions in patients with coronary heart disease

作　　者：格日勒 吴云 杨丽云 Gerile;Wu Yun;Yang Liyun(Department of Cardiovascular Medicine,People's Hospital of Inner Mongolia,Hohhot 010017,China;不详)

机构地区：[1]内蒙古自治区人民医院心血管内科,呼和浩特010017 [2]内蒙古自治区人民医院干部保健所,呼和浩特010017

出　　处：《中国循证心血管医学杂志》2022年第4期442-446,共5页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：内蒙古自治区自然科学基金项目(2017MS08158)。

摘　　要：目的 探讨乙醛脱氢酶2(ALDH2)基因G487A位点多态性与冠状动脉粥样硬化性心脏病(冠心病)患者冠状动脉(冠脉)病变程度的相关性。方法 选择2018年1月至2020年3月于内蒙古自治区人民医院心血管内科收治的冠心病患者(冠心病组,n=168)和年龄、性别相匹配的门诊体检志愿者(对照组,n=170)为研究对象。采集外周静脉血,TaqMan探针SNP基因分型技术检测ALDH2基因G487A位点多态性,并分析其与冠心病易感以及冠脉病变程度的关系。结果 G487A位点ALDH2基因型频率分布均符合Hardy-Weinberg平衡定律(P>0.05),冠心病组和对照组ALDH2基因型、等位基因差异显著(P<0.05),GA基因型(OR=1.524,95%CI:1.435~1.663)、AA基因型(OR=1.739,95%CI:1.656~1.867)、A等位基因(OR=1.721,95%CI:1.603~1.851)与冠心病风险增加有关(P<0.05)。GA+AA基因型、GG基因型冠脉病变支数、冠脉狭窄程度、冠脉病变程度差异显著(P<0.001),ALDH2基因突变与冠脉病变支数、冠脉狭窄率、SYNTAX积分呈正相关(r=0.723、0.603、0.559,P均<0.001)。回归分析示合并高血压、合并糖尿病、冠心病家族史、ALDH2基因G487A位点多态性与冠心病的发生相关(P<0.05)。结论 ALDH2基因G487A位点多态性可能与冠心病易感和冠脉病变程度有关,携带A等位基因个体患冠心病风险更高,冠脉病变程度更为严重。Objective To discuss the correlation between acetaldehyde dehydrogenase 2(ALDH2) gene G487A polymorphism and severity of coronary artery lesions in patients with coronary heart disease(CHD).Methods CHD patients(n=168) were chosen into CHD group(n=168) and volunteers of physical examinations with matched ages and genders were chosen into control group(n=170) from Department of Cardiovascular Medicine in People’s Hospital of Inner Mongolia from Jan.2018 to Mar.2020.The samples of peripheral venous blood were collected in 2 groups.The polymorphism of ALDH2 gene at G487A locus was detected by using SNP genotyping technique with TaqMan probe.The relationship among polymorphism of ALDH2 gene at G487A locus,CHD susceptibility and severity of coronary artery lesions was analyzed.Results The frequency distributions of ALDH2 genotypes at G487A locus were consistent with Hardy-Weinberg equilibrium law(P>0.05).ALDH2 genotypes and alleles had significant differences between CHD group and control group(P<0.05).GA genotype(OR=1.524,95%CI:1.435~1.663),AA genotype A(OR=1.739,95%CI:1.656~1.867) and allele A(OR=1.721,95%CI:1.603~1.851) were correlated to CHD risk increase(P<0.05).The number of coronary artery lesions,severity of coronary artery stenosis and severity of coronary artery lesions were significantly different between GA+AA genotype and GG genotype(P<0.001).The mutation of ALDH2 gene was positively correlated to number of coronary artery lesions(r=0.723),coronary artery stenosis rate(r=0.603) and SYNTAX integrals(r=0.559,all P<0.001).The results of regression analysis showed that complicated hypertension,complicated diabetes,family history of CHD and ALDH2 gene G487A polymorphism were correlated to CHD incidence(P<0.05).Conclusion ALDH2gene G487A polymorphism is possibly correlated to CHD susceptibility and severity of coronary artery lesions,and the individuals carrying allele A have a higher risk of CHD and more severe coronary artery disease.

关 键 词：乙醛脱氢酶2 多核苷酸 多态性 冠心病 冠状动脉狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]