急性非ST段抬高型心肌梗死患者血浆NT-proBNP、hs-CRP水平与冠状动脉病变程度的相关性  

Correlation between levels of N-terminal pro-brain natriuretic peptide and high sensitivity C-reactive protein and severity of coronary artery lesions in patients with acute non-ST-segment elevation myocardial infarction

作　　者：李晓丽[1] 侯东燕 池洪杰[1] Li Xiaoli;Hou Dongyan;Chi Hongjie(Department of Cardiology,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100026,China;不详)

机构地区：[1]首都医科大学附属北京朝阳医院心内科,北京100026

出　　处：《中国循证心血管医学杂志》2022年第4期465-467,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的 分析急性非ST段抬高型心肌梗死(NSTEMI)患者N末端脑钠肽前体(NTproBNP)、超敏-C反应蛋白(hs-CRP)水平与冠状动脉(冠脉)病变程度的相关性。方法 将2016年8月至2017年8月于北京朝阳医院收治的120例NSTEMI患者纳入研究组,将同时期在我院行常规体检的120例健康志愿者纳入对照组,两组均行血浆NT-proBNP、hs-CRP水平检测并比较其差异;对NSTEMI患者行冠脉造影检查,根据检查结果将其分为单支病变组与多支病变组,比较两个亚组间的血浆NTproBNP、hs-CRP水平;应用Pearson相关性分析法与多元Logistic分析法分析NT-proBNP、hs-CRP水平与冠脉病变的相关性。结果 研究组的NT-proBNP、hs-CRP水平均高于对照组(P<0.05);冠脉造影检查检出单支病变42例(单支病变组),多支病变78例(多支病变组),多支病变组的NT-proBNP、hs-CRP水平均高于单支病变组(P<0.05);Pearson相关性分析结果显示,NT-proBNP、hs-CRP水平与冠脉病变程度之间呈明显的正相关性(P<0.05);多元Logistic分析结果显示,NT-proBNP、hs-CRP均为冠脉病变的危险因素。结论 NSTEMI患者血浆NT-proBNP、hs-CRP水平与冠脉病变程度之间存在相关性,NT-proBNP、hs-CRP检测对NSTEMI诊断及冠脉病变程度评估具有一定的指导作用。Objective To analyze the correlation between the levels of plasma N-terminal pro-brain natriuretic peptide(NT-proBNP) and high sensitivity C-reactive protein(hs-CRP) and severity of coronary artery lesions in patients with acute non-ST-segment elevation myocardial infarction(NSTEMI).Methods NSTEMI patients(n=120) were selected into study group and healthy controls(n=120) were selected into control group from Beijing Chaoyang Hospital from Aug.2016 to Aug.2017.The levels of NT-proBNP and hs-CRP were detected and compared in 2 groups.NSTEMI patients were given examination of coronary angiography(CAG),and then divided,according to CAG results,into single-vessel lesion subgroup and multi-vessel lesion subgroup.The levels of plasma NT-proBNP and hs-CRP were compared between 2 subgroups.The correlation among NT-proBNP and hs-CRP was analyzed by using Pearson correlation analysis and multiple Logistic regression analysis.Results The levels of NT-proBNP and hs-CRP were higher in study group than those in control group(P<0.05).The results of CAG examination showed that there were 42 cases in single-vessel lesion subgroup and 78 cases in multi-vessel lesion subgroup.The levels of NT-proBNP and hs-CRP were higher in multi-vessel lesion subgroup than those in single-vessel lesion subgroup(P<0.05).The results of Pearson correlation analysis showed that the levels of NTproBNP and hs-CRP were positively correlated to the severity of coronary artery lesion significantly(P<0.05).The results of multiple Logistic regression analysis showed that the levels of NT-proBNP and hs-CRP were risk factors of coronary artery lesion.Conclusion There is a certain correlation between the levels of plasma NT-proBNP and hs-CRP and the severity of coronary artery lesions in NSTEMI patients.The detection of NT-proBNP and hs-CRP plays a guiding role in NSTEMI severity diagnosis and assessment.

关 键 词：急性非ST段抬高型心肌梗死 N末端脑钠肽前体 超敏-C反应蛋白 冠脉病变程度 

分 类 号：R542.22[医药卫生—心血管疾病]