血液透析患者微炎症状态下血脂及钙磷指标与hs-CRP水平的相关性研究  

Correlation between serum lipid,calcium and phosphorus and hS-CRP level in hemodialysis patients with microinflammation

作　　者：吕俊智 LYU Junzhi(The Third Department of Internal Medicine,Second People′s Hospital of Shanwei,Shanwei Yihui Foundation Hospital,Guangdong Province,Shanwei516600,China)

机构地区：[1]广东省汕尾市第二人民医院汕尾逸挥基金医院内三科,广东汕尾516600

出　　处：《中国当代医药》2022年第16期136-139,共4页China Modern Medicine

基　　金：广东省汕尾市科技计划项目名称(2018C009)。

摘　　要：目的探讨血液透析患者微炎症状态下血脂代谢、钙磷代谢与超敏C反应蛋白(hs-CRP)水平的相关性。方法选取2019年1月至2020年4月在汕尾市第二人民医院接受血液透析治疗的58例微炎症状态患者作为透析组,选取同期接受健康体检的60例健康志愿者为对照组。比较两组的hs-CRP、尿蛋白、血肌酐(SCr)、血尿素氮(BUN)、三酰甘油(TG)、血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)、血钙、血磷及甲状旁腺激素(PTH)等指标,分析血脂、钙磷与hs-CRP的相关性。结果透析组患者的hs-CRP、SCr、BUN、TC、血钙、血磷、钙磷乘积及PTH水平均高于对照组,HDL低于对照组,差异有统计学意义(P<0.05)。两组的TG、LDL水平比较,差异无统计学意义(P>0.05)。血液透析患者的血脂、钙磷水平与hs-CRP均无相关性(P>0.05)。结论长期血液透析患者处于微炎症状态时,其血脂水平、钙磷水平均存在一定异常,但其异常情况与hs-CRP指标无明显关联。Objective To explore the correlation between metabolism of blood lipid,calcium,and phosphorus and high-sensitivity C-reactive protein(hs-CRP)level in hemodialysis patients at the micro-inflammatory state.Methods Fifty-eight patients with microinflammation who received hemodialysis treatment in the Second People′s Hospital of Shanwei from January 2019 to April 2020 were selected as the dialysis group,and 60 healthy volunteers who received physical examination during the same period were selected as the control group.hs-CRP,urine protein,serum creatinine(SCr),blood urea nitrogen(BUN),triglyceride(TG),serum total cholesterol(TC),high density lipoprotein cholesterol(HDL),low density lipoprotein cholesterol(LDL),blood calcium,blood phosphorus and parathyroid hormone(PTH)were compared between the two groups.The correlation of blood lipid,calcium and phosphorus with hs-CRP was analyzed.Results The levels of hs-CRP,SCr,BUN,TC,blood calcium,blood phosphorus,calcium phosphorus product and PTH in dialysis group were higher than those in control group,while HDL was lower than control group,the differences were statistically significant(P<0.05).There were no significant differences in TG and LDL levels between the two groups(P>0.05).There was no correlation between serum lipid,calcium and phosphorus levels and hs-CRP in hemodialysis patients(P>0.05).Conclusion When long-term hemodialysis patients are in a micro-inflammatory state,there are certain abnormalities in blood lipid levels and calcium and phosphorus levels,but the abnormal conditions are not significantly related to hs-CRP.

关 键 词：血液透析 微炎症 血脂水平 钙磷水平 相关性 

分 类 号：R459.5[医药卫生—治疗学]