串联反应合成α-叠氮酮类化合物及其衍生化  

Tandem Reaction to Synthesizeα-azidosterone Compounds and Their Derivatization

作　　者：李帅 阿布都热西提·阿布力克木[1] Li Shuai;Abulikemu Abudu Rexit(College of Chemistry and Chemical Engineering,Xinjiang Normal University,Urumqi 830054,China)

机构地区：[1]新疆师范大学化学化工学院,新疆乌鲁木齐830054

出　　处：《广东化工》2022年第10期28-31,共4页Guangdong Chemical Industry

基　　金：新疆维吾尔自治区高校科研计划自然科学重点项目(No.XJEDU202I015)。

摘　　要：鉴于α-叠氮酮类化合物在有机合成和生物医学中被广泛的应用;且它与炔烃的衍生产物1,2,3-三氮唑类化合物在抗癌症、抗结核、抗HIV等方面表现出很好的生物活性,所以α-叠氮酮类化合物及其衍生化的合成方法备受关注。因此,发展简洁、高效构建α-叠氮酮类化合物及其衍生化的合成方法具有重要的意义。本文首先采用α-一溴苯乙酮类化合物为原料合成了一系列α-叠氮酮类化合物。再次采用α-一溴苯乙酮类化合物作为原料通过一锅串联反应高效合成了一系列1,2,3-三氮唑类化合物。该方法具有原料易得、溶剂绿色、底物适用范围广等优点,已知产物均经^(1)H NMR结构确证,未知物经^(1)H NMR、^(13)C NMR结构确证。In view of the fact thatα-azidosterone compounds are widely used in organic synthesis and biomedicine,and it and the derivatives of alkyne hydrocarbons 1,2,3-triazoles show good biological activity in anti-cancer,anti-tuberculosis,anti-HIV and other aspects,so the synthesis methods ofα-azidosterone compounds and their derivatization have attracted much attention.Therefore,it is of great significance to develop a concise and efficient synthesis method for constructingα-azidosterone compounds and their derivatization.In this paper,a series ofα-azidosterone compounds were synthesized usingα-monobromoacetophenone compounds as raw materials.Again,a series of 1,2,3-triazole compounds were efficiently synthesized by usingα-monobromoa-cetophenone compounds as raw materials through a pot series reaction.The method has the advantages of easy availability of raw materials,green solvents,and wide application range of substrates,and the known products are confirmed by the ^(1)H NMR structure,and the unknowns are confirmed by the ^(1)H NMR and ^(13)C NMR structures.

关 键 词：α-溴代甲基酮类化合物 α-叠氮酮类化合物 一锅法串联反应 点击反应 1 2 3-三氮唑 

分 类 号：TQ[化学工程]