首发抑郁症伴阻塞性睡眠呼吸暂停患者的嗅觉功能  

Olfactory function in patients with first-episode major depressive disorder comorbid obstructive sleep apnea

作　　者：孙颖慧[1] 钟莹[2] 尹析凡[3] SUN Yinghui;ZHONG Ying;YIN Xifan(Department of Otolaryngology,the Third Hospital of Huzhou,Huzhou 313000,Zhejiang Province,China;Department of Respir-atory,the Third Hospital of Huzhou,Huzhou 313000,Zhejiang Province,China;Department of psychosomatic,the Third Hospital of Huzhou,Huzhou 313000,Zhejiang Province,China)

机构地区：[1]湖州市第三人民医院耳鼻咽喉科,浙江湖州313000 [2]湖州市第三人民医院呼吸内科,浙江湖州313000 [3]湖州市第三人民医院心身科,浙江湖州313000

出　　处：《中国心理卫生杂志》2022年第7期557-562,共6页Chinese Mental Health Journal

基　　金：浙江省湖州市科技局公益性技术应用研究(2019GYB55)。

摘　　要：目的:了解伴阻塞性睡眠呼吸暂停(OSA)首发抑郁症患者的嗅觉功能,分析嗅觉功能的相关因素。方法:对143例首发抑郁症患者进行多导睡眠监测(PSG)、T&T嗅觉检查。以PSG结果呼吸暂停低通气指数(AHI)≥5次/h为抑郁伴OSA组(n=87),AHI<5次/h为单纯抑郁组(n=56)。采用多元逐步回归分析伴OSA首发抑郁症患者嗅觉功能的相关因素。结果:抑郁伴OSA组的嗅觉识别阈值、嗅觉障碍发生率高于单纯抑郁组(均P<0.05),以嗅觉减退为主(93.9%,46/49)。伴重度OSA的首发抑郁症患者嗅觉识别阈值、嗅觉障碍发生率高于轻、中度组(均P<0.05)。多元逐步回归分析显示,AHI指数和HAMD得分与嗅觉识别阈值正相关(β=0.05~0.30,均P<0.01)。结论:本研究显示伴阻塞性睡眠呼吸暂停首发抑郁症患者较单纯首发抑郁症患者嗅觉障碍更显著,以嗅觉减退为主。Objective:To investigate the olfactory function in patients with first-episode depression comorbid obstructive sleep apnea(OS A).Methods:Totally 143 patients with first-episode depression were monitored by polysomnography(PSG)overnight and examined by T&T olfactometer test.The patients with apnea hypopnea index(AHI)≥5 times/h were as depression comorbid OSA group(n=87),and those with AHI<5 times/h were in depression group(n=56).Multiple stepwise regression was used to analysis the related factors of olfactory disorders in patients with depression comorbid OS A.Results:The olfactory recognition threshold and rate of olfactory disorder were higher in the patients in depression comorbid OSA group than in the depression group.Hyposmia was the main olfactory disorder in depression comorbid OSA group(93.9%,46/49).The olfactory recognition threshold and rate of olfactory disorder were higher in the patients with severe OSA than in those with mild to moderate OSA(Ps<0.05).Multiple stepwise regression showed that the rate of olfactory disorder was positively correlated with the HAMD scores and AHI(Ps<0.05).Conclusion:It suggests that the patients with first-episode depression comorbid obstructive sleep apnea have more significant olfactory disorder than those without obstructive sleep apnea,mainly hyposmia.

关 键 词：阻塞性睡眠呼吸暂停 抑郁 嗅觉功能 

分 类 号：R563.8[医药卫生—呼吸系统] R749.41[医药卫生—内科学]